In 2019 EUR J MED CHEM published article about ACUTE MYELOID-LEUKEMIA; KINASE INHIBITOR; MUTATIONS; SORAFENIB; DISCOVERY; OUTCOMES; MUTANTS; POTENT in [Heng, Hao; Wang, Zhijie; Li, Hongmei; Huang, Yatian; Lan, Qingyuan; Guo, Xiaoxing; Zhang, Liang; Lu, Shuai] China Pharmaceut Univ, Sch Sci, Nanjing 211198, Jiangsu, Peoples R China; [Zhi, Yanle] Henan Univ Chinese Med, Sch Pharm, Zhengzhou 450046, Henan, Peoples R China; [Cai, Jiongheng; Qin, Tianren; Xiang, Li; Wang, Shuxian] China Pharmaceut Univ, Sch Pharm, Nanjing 210009, Jiangsu, Peoples R China; [Chen, Yadong] China Pharmaceut Univ, Lab Mol Design & Drug Discovery, Nanjing 211198, Jiangsu, Peoples R China; [Lu, Tao] China Pharmaceut Univ, State Key Lab Nat Med, Nanjing 210009, Jiangsu, Peoples R China in 2019, Cited 32. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7. Safety of 4-Nitrobenzoic acid
FLT3 mutation is among the most common genetic mutations in acute myeloid leukemia (AML), which is also related with poor overall survival and refractory in AML patients. Recently, FLT3 inhibitors have been approved for AML therapy. Herein, a series of new compounds with pyrazole amine scaffold was discovered, which showed potent inhibitory activity against FLT3-ITD and significant selectivity against both FLT3-ITD and AML cells expressing FLT3-ITD. Compound 46, possessing the most promising cellular activity, blocked the autophosphorylation of FLT3 pathway in MV4-11 cell line. Furthermore, the apoptosis and downregulation of P-STAT5 were also observed in tumor cells extracted from the MV411 cell xenografts model upon compound 46 treatment. Compound 46 was also metabolically stable in vitro and suppressed tumor growth significantly in MV4-11 xenografts model in vivo. Compound 46 showed no toxicity to the viscera of mice and caused no decrease in body weight of mice. In conclusion, the results of this study could provide valuable insights into discovery of new FLT3 inhibitors, and compound 46 was worthy of further development as potential drug candidate to treat AML (C) 2019 Elsevier Masson SAS. All rights reserved.
Safety of 4-Nitrobenzoic acid. Welcome to talk about 62-23-7, If you have any questions, you can contact Heng, H; Wang, ZJ; Li, HM; Huang, YT; Lan, QY; Guo, XX; Zhang, L; Zhi, YL; Cai, JH; Qin, TR; Xiang, L; Wang, SX; Chen, YD; Lu, T; Lu, S or send Email.
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Phthalazine – Wikipedia,
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