Recently I am researching about SM PROTEINS; PRMT5; METHYLATION; GROWTH; IDENTIFICATION; COMPLEX; PICLN, Saw an article supported by the Ministry of Science and Technology of ChinaMinistry of Science and Technology, China [2015CB910304]; National Science and Technology Major Project [2018ZX09711002-004-013]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81625022, 91853205, 81430084, 81803438]; Shandong Provincial Natural Science FoundationNatural Science Foundation of Shandong Province [ZR2017BH038]; K.C. Wong Education Foundation [XDA12020353]; Chinese Academy of SciencesChinese Academy of Sciences [XDA12020353]; Science and Technology Commission of Shanghai MunicipalityScience & Technology Commission of Shanghai Municipality (STCSM) [18431907100]. Product Details of 62-23-7. Published in ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER in ISSY-LES-MOULINEAUX ,Authors: Shao, JW; Zhu, KK; Du, DH; Zhang, YY; Tao, HR; Chen, ZF; Jiang, HL; Chen, KX; Luo, C; Duan, WH. The CAS is 62-23-7. Through research, I have a further understanding and discovery of 4-Nitrobenzoic acid
Protein arginine methyltransferases 5 (PRMT5) represents an attractive drug target in epigenetic field for the treatment of leukemia and lymphoma. Here, a series of N-(3-(3,4-dihydroisoquinolin-2(1H)-yl)-2-hydroxypropyl)amide derivatives targeting PRMT5 were designed with structure-based approach and synthesized. Among them, compound 46 showed potent and selective PRMT5 inhibition activity with an IC50 of 8.5 nM, which was approximately equivalent with the phase 1 clinical trial PRMT5 inhibitor GSK-3326595 (IC50 = 5.5 nM). Compound 46 also displayed pronounced anti-proliferative activity in MV4-11 cells (GI(50) =18 nM) and antitumor activity in MV4-11 mouse xenografts model. This molecule can serve as an excellent tool compound for probing the biological function of PRMT5. (C) 2018 Published by Elsevier Masson SAS.
Product Details of 62-23-7. Welcome to talk about 62-23-7, If you have any questions, you can contact Shao, JW; Zhu, KK; Du, DH; Zhang, YY; Tao, HR; Chen, ZF; Jiang, HL; Chen, KX; Luo, C; Duan, WH or send Email.
Reference:
Phthalazine – Wikipedia,
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