Authors Testolin, G; Cirnski, K; Rox, K; Prochnow, H; Fetz, V; Grandclaudon, C; Mollner, T; Baiyoumy, A; Ritter, A; Leitner, C; Krull, J; van den Heuvel, J; Vassort, A; Sordello, S; Hamed, MM; Elgaher, WAM; Herrmann, J; Hartmann, RW; Muller, R; Bronstrup, M in ROYAL SOC CHEMISTRY published article about CONSTITUENT AMINO-ACIDS; DNA MINOR-GROOVE; ABSOLUTE-CONFIGURATION; ALBICIDIN DERIVATIVES; MARFEYS METHOD; AMINOGLYCOSIDE; RECOGNITION; INHIBITOR; DISCOVERY; PROBES in [Testolin, Giambattista; Rox, Katharina; Prochnow, Hans; Fetz, Verena; Grandclaudon, Charlotte; Mollner, Tim; Baiyoumy, Alain; Ritter, Antje; Leitner, Christian; Krull, Jana; Broenstrup, Mark] Helmholtz Ctr Infect Res, Dept Chem Biol, Inhoffenstr 7, D-38124 Braunschweig, Germany; [Cirnski, Katarina; Rox, Katharina; Grandclaudon, Charlotte; Leitner, Christian; Herrmann, Jennifer; Mueller, Rolf; Broenstrup, Mark] German Ctr Infect Res DZIF, Site Hannover Braunschwe, Germany; [Cirnski, Katarina; Hamed, Mostafa M.; Elgaher, Walid A. M.; Herrmann, Jennifer; Hartmann, Rolf W.; Mueller, Rolf] Helmholtz Inst Pharmaceut Res Saarland, Univ Campus E8-1, D-66123 Saarbrucken, Germany; [van den Heuvel, Joop] Helmholtz Ctr Infect Res, Grp Recombinant Prot Express, Inhoffenstr 7, D-38124 Braunschweig, Germany; [Vassort, Aurelie] Evotec ID, 1541 Ave Marcel Merieux, F-69289 Marcy Letoile, France; [Sordello, Sylvie] Evotec ID, Alderley Pk SK10 4TG, Cheshire, England; [Broenstrup, Mark] Leibniz Univ Hannover, Ctr Biomol Drug Res BMWZ, D-30167 Hannover, Germany in 2020.0, Cited 45.0. Name: 4-Nitrobenzoic acid. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7
There is an alarming scarcity of novel chemical matter with bioactivity against multidrug-resistant Gram-negative bacterial pathogens. Cystobactamids, recently discovered natural products from myxobacteria, are an exception to this trend. Their unusual chemical structure, composed of oligomeric para-aminobenzoic acid moieties, is associated with a high antibiotic activity through the inhibition of gyrase. In this study, structural determinants of cystobactamid’s antibacterial potency were defined at five positions, which were varied using three different synthetic routes to the cystobactamid scaffold. The potency against Acinetobacter baumannii could be increased ten-fold to an MIC (minimum inhibitory concentration) of 0.06 mu g mL(-1), and the previously identified spectrum gap of Klebsiella pneumoniae could be closed compared to the natural products (MIC of 0.5 mu g mL(-1)). Proteolytic degradation of cystobactamids by the resistance factor AlbD was prevented by an amide-triazole replacement. Conjugation of cystobactamid’s N-terminal tetrapeptide to a Bodipy moiety induced the selective localization of the fluorophore for bacterial imaging purposes. Finally, a first in vivo proof of concept was obtained in an E. coli infection mouse model, where derivative 22 led to the reduction of bacterial loads (cfu, colony-forming units) in muscle, lung and kidneys by five orders of magnitude compared to vehicle-treated mice. These findings qualify cystobactamids as highly promising lead structures against infections caused by Gram-positive and Gram-negative bacterial pathogens.
Name: 4-Nitrobenzoic acid. Bye, fridends, I hope you can learn more about C7H5NO4, If you have any questions, you can browse other blog as well. See you lster.
Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem