Authors Santoso, KT; Brett, MW; Cheung, CY; Cook, GM; Stocker, BL; Timmer, MSM in WILEY-V C H VERLAG GMBH published article about II NADH DEHYDROGENASE; DERIVATIVES; OXIDOREDUCTASE; ACTIVATION; INHIBITORS; SERIES in [Santoso, Kristiana T.; Brett, Matthew W.; Stocker, Bridget L.; Timmer, Mattie S. M.] Victoria Univ Wellington, Sch Chem & Phys Sci, POB 600, Wellington 6140, New Zealand; [Santoso, Kristiana T.; Brett, Matthew W.; Stocker, Bridget L.; Timmer, Mattie S. M.] Victoria Univ Wellington, Ctr Biodiscovery, POB 600, Wellington 6140, New Zealand; [Santoso, Kristiana T.; Cook, Gregory M.; Stocker, Bridget L.; Timmer, Mattie S. M.] Univ Auckland, Maurice Wilkins Ctr Mol Biodiscovery, Auckland, New Zealand; [Cheung, Chen-Yi; Cook, Gregory M.] Univ Otago, Dept Microbiol & Immunol, Sch Biomed Sci, Dunedin, New Zealand in 2020, Cited 39. Recommanded Product: 62-23-7. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7
Drug-resistant strains of Mycobacterium tuberculosis are on the rise and have resulted in an urgent need to develop new tuberculosis (TB) drugs. Herein, the development of chromonyl-pyrimidines as a new TB drug scaffold is presented. A library of eleven chromonyl-pyrimidines was synthesised, from which lead compound 6-((2-amino-6-methylpyrimidin-4-yl)amino)-3-benzoyl-2-phenyl-4H-chromen-4-one (MIC=36 mu M against M. tuberculosis) was identified. A second-generation library of seven aryl-substituted chromonyl-pyrimidines was then prepared, with six chromonyl-pyrimidines exhibiting an improved M. tuberculosis growth inhibition (MIC=12.5 mu M). From this work, the potential of chromonyl-pyrimidines as therapeutics for TB is demonstrated.
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Phthalazine – Wikipedia,
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