COA of Formula: C7H5NO4. Recently I am researching about IN-VITRO; INHIBITION; GP; EFFLUX; CELLS; MDR; PHARMACOKINETICS; MODULATION; MECHANISM; CANCER, Saw an article supported by the National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81872733, 81872734, 81803353]; Jiangsu Qing Lan Project; Foundation of Jiangsu Provincial Key Laboratory of Coastal Wetland Bioresources and Environmental Protection [JKLBS2017011]. Published in ACADEMIC PRESS INC ELSEVIER SCIENCE in SAN DIEGO ,Authors: Qiu, QQ; Zhu, JL; Chen, QT; Jiang, ZQ; Xu, JT; Jiang, XT; Huang, WL; Liu, ZQ; Ye, J; Xu, XJ. The CAS is 62-23-7. Through research, I have a further understanding and discovery of 4-Nitrobenzoic acid
P-glycoprotein (P-gp)-mediated multidrug resistance (MDR) is a major impediment for clinical cancer therapy. 19 novel aromatic amides with triazole-core as MDR reversal agents were designed and synthesized via click chemistry to reverse MDR. Among them, compound 42 was identified as the most promising candidate with high potency (EC50 = 78.1 +/- 5.4 nM), low cytotoxity (SI > 1282) and persistent duration in reversing doxorubicin (DOX) resistance in K562/A02 cells. 42 also enhanced the potency of other P-gp associated cytotoxic agents with different structures. In further study, remarkably increased intracellular accumulation of Rh123 and DOX in K562/A02 cells was achieved by compound 42, while CYP3A4 activity had no change by compound 42. These results indicate that compound 42 as a relatively safe modulator of P-gp-mediated MDR has good potential for further development.
Welcome to talk about 62-23-7, If you have any questions, you can contact Qiu, QQ; Zhu, JL; Chen, QT; Jiang, ZQ; Xu, JT; Jiang, XT; Huang, WL; Liu, ZQ; Ye, J; Xu, XJ or send Email.. COA of Formula: C7H5NO4
Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem