Month: December 2021

In 2019 EUR J MED CHEM published article about ACUTE MYELOID-LEUKEMIA; KINASE INHIBITOR; MUTATIONS; SORAFENIB; DISCOVERY; OUTCOMES; MUTANTS; POTENT in [Heng, Hao; Wang, Zhijie; Li, Hongmei; Huang, Yatian; Lan, Qingyuan; Guo, Xiaoxing; Zhang, Liang; Lu, Shuai] China Pharmaceut Univ, Sch Sci, Nanjing 211198, Jiangsu, Peoples R China; [Zhi, Yanle] Henan Univ Chinese Med, Sch Pharm, Zhengzhou 450046, Henan, Peoples R China; [Cai, Jiongheng; Qin, Tianren; Xiang, Li; Wang, Shuxian] China Pharmaceut Univ, Sch Pharm, Nanjing 210009, Jiangsu, Peoples R China; [Chen, Yadong] China Pharmaceut Univ, Lab Mol Design & Drug Discovery, Nanjing 211198, Jiangsu, Peoples R China; [Lu, Tao] China Pharmaceut Univ, State Key Lab Nat Med, Nanjing 210009, Jiangsu, Peoples R China in 2019, Cited 32. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7. Safety of 4-Nitrobenzoic acid

FLT3 mutation is among the most common genetic mutations in acute myeloid leukemia (AML), which is also related with poor overall survival and refractory in AML patients. Recently, FLT3 inhibitors have been approved for AML therapy. Herein, a series of new compounds with pyrazole amine scaffold was discovered, which showed potent inhibitory activity against FLT3-ITD and significant selectivity against both FLT3-ITD and AML cells expressing FLT3-ITD. Compound 46, possessing the most promising cellular activity, blocked the autophosphorylation of FLT3 pathway in MV4-11 cell line. Furthermore, the apoptosis and downregulation of P-STAT5 were also observed in tumor cells extracted from the MV411 cell xenografts model upon compound 46 treatment. Compound 46 was also metabolically stable in vitro and suppressed tumor growth significantly in MV4-11 xenografts model in vivo. Compound 46 showed no toxicity to the viscera of mice and caused no decrease in body weight of mice. In conclusion, the results of this study could provide valuable insights into discovery of new FLT3 inhibitors, and compound 46 was worthy of further development as potential drug candidate to treat AML (C) 2019 Elsevier Masson SAS. All rights reserved.

Safety of 4-Nitrobenzoic acid. Welcome to talk about 62-23-7, If you have any questions, you can contact Heng, H; Wang, ZJ; Li, HM; Huang, YT; Lan, QY; Guo, XX; Zhang, L; Zhi, YL; Cai, JH; Qin, TR; Xiang, L; Wang, SX; Chen, YD; Lu, T; Lu, S or send Email.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

An article Tandem reaction strategy of the Passerini/Wittig reaction based on the in situ capture of isocyanides: One-pot synthesis of heterocyclemcs WOS:000466451800016 published article about EFFICIENT SYNTHESIS; CRYSTAL-STRUCTURE; STEREOSELECTIVE-SYNTHESIS; CHEMICAL-SYNTHESIS; ISONITRILES; ALPHA; DERIVATIVES; CASCADE; FACILE in [Liu, Ming-Guo; Liu, Na; Xu, Wen-Heng; Wang, Long] China Three Gorges Univ, Coll Mat & Chem Engn, Key Lab Inorgan Nonmetall Crystalline & Energy Co, Yichang 443002, Hubei, Peoples R China in 2019.0, Cited 103.0. Category: phthalazines. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7

This paper reports the tandem reaction strategy of the Passerini/Wittig reaction based on the in situ capture of isocyanides. According to this strategy, plenty of isocyanides have been synthesized, which is immediately used for the tandem reaction of Passerini/Wittig reaction in one pot. Compared to the previous work, this strategy avoids the separation, purification, and storage of isocyanides, which prominently solves the problems of isocyanide-based multicomponent reaction such as: (a) The environmentally unfriendly (strong foul odor), (a) the labile of isocyanides, (c) high toxicity of isocyanides. In the meantime, in order to expand the application scope of our strategy, 1H-isochromenes and 3H-2-benzoxepin-1-ones have also been synthesized, which undergoes four-step transformations in one-pot. In addition, a relatively credible reaction mechanism has also been proposed, based on a series of control experiments. Furthermore, preliminary testing was performed on biological activity of some obtained compounds; These results showed that the synthesized compounds exhibited certain activity over P. digitatum and P. italicum. (C) 2019 Elsevier Science. All rights reserved. (C) 2019 Elsevier Ltd. All rights reserved.

Category: phthalazines. Bye, fridends, I hope you can learn more about C7H5NO4, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Application In Synthesis of 4-Nitrobenzoic acid. In 2020.0 J ORG CHEM published article about CASCADE REACTIONS; MICHAEL REACTION; CONDENSATIONS; CONSTRUCTION in [Hu, Sha; Wang, Jiaqi; Huang, Guanxin; Zhu, Kejie; Chen, Fener] Fudan Univ, Dept Chem, Shanghai 200433, Peoples R China; [Chen, Fener] Zhejiang Univ Technol, Inst Pharmaceut Sci & Technol, 18 Chao Wang Rd, Hangzhou 310014, Peoples R China in 2020.0, Cited 48.0. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7.

An organocatalytic asymmetric enantioselective domino oxa-Michael-Mannich-[1,3]-amino rearrangement reaction of N-tosylsalicylimines with a wide range of alpha,beta-unsaturated aldehydes utilizing diarylprolinol silyl ether catalysis is described. The catalytic reactions proceed with excellent enantioselectivity (up to 99% ee) to produce the corresponding chair N-tosylimines-chromenes with a yield of up to 99%, tolerating a range of functional groups. This methodology offers a new method with great potential to further extend the synthetic power and versatility of chiral aminocatalysis.

Bye, fridends, I hope you can learn more about C7H5NO4, If you have any questions, you can browse other blog as well. See you lster.. Application In Synthesis of 4-Nitrobenzoic acid

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Computed Properties of C7H5NO4. In 2020.0 APPL CLAY SCI published article about SELECTIVE OXIDATION; HIGHLY EFFICIENT; SOLVENT-FREE; WATER; HYDROGEN; MNO2; NANOPARTICLES; DEGRADATION; ALDEHYDES; CATALYST in [Pazoki, Farzane; Shamsayei, Maryam; Bagheri, Sepideh; Yazdani, Elahe; Heydari, Akbar] Tarbiat Modares Univ, Fac Sci, Dept Chem, Tehran 1411713116, Iran in 2020.0, Cited 38.0. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7.

In the present work, MnO2@Mg-Al layered double hydroxide (LDH) has been prepared via a simple coprecipitation method and characterized successfully. Two products are formed from benzyl alcohol oxidation over MnO2@Mg-Al layered double hydroxide (LDH): benzaldehyde and benzoic acid. This oxidation was carried out with three different parameters: oxidant, solvent, and temperature. In addition, MnO2@Mg-Al LDHs could be easily recovered and reused for five times without any loss of activity.

Computed Properties of C7H5NO4. Welcome to talk about 62-23-7, If you have any questions, you can contact Pazoki, F; Shamsayei, M; Bagheri, S; Yazdani, E; Heydari, A or send Email.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

An article Metal-free tandem reaction synthesis of spiro-cyclopropyl fused pyrazolin-5-one derivatives WOS:000459735400015 published article about CATALYTIC ASYMMETRIC-SYNTHESIS; PARA-QUINONE METHIDES; UNSATURATED PYRAZOLONES; SULFUR YLIDES; SPIROPYRAZOLONES; CYCLIZATION; OXINDOLES; SPIROCYCLOPROPANATION; SPIROOXINDOLES; IDENTIFICATION in [Xu, Yan-Jun] Sichuan Normal Univ, Coll Chem & Mat Sci, Chengdu 610066, Sichuan, Peoples R China; [Liu, Man; Liu, Chen-Fei; Zhang, Jing; Dong, Lin] Sichuan Univ, West China Sch Pharm, Educ Minist, Key Lab Drug Targeting & Drug Delivery Syst, Chengdu 610041, Sichuan, Peoples R China in 2019.0, Cited 68.0. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7. HPLC of Formula: C7H5NO4

A highly efficient cascade annulation approach was developed for the synthesis of novel spiro-cyclopropyl fused pyrazolin-5-ones from pyrazole-3-ketone substrates and two-component sulfur ylides in an acidic environment. This metal-free one-pot reaction has the advantages of easily available active materials, simple operation and brand new spirocyclic skeletons.

Bye, fridends, I hope you can learn more about C7H5NO4, If you have any questions, you can browse other blog as well. See you lster.. HPLC of Formula: C7H5NO4

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Formula: C7H5NO4. In 2019.0 J PHYS CHEM C published article about SUBSTITUTED TRIPHENYLAMINE; STRUCTURE-PROPERTY; TRANSPORTING MATERIALS; CONJUGATED POLYIMIDE; AROMATIC POLYAMIDES; ELECTROLUMINESCENT; OXADIAZOLE; LIGHT; DERIVATIVES; FLUORESCENT in [Bejan, Andra-Elena; Constantin, Catalin-Paul; Damaceanu, Mariana-Dana] Petru Poni Inst Macromol Chem, Polycondensat & Thermostable Polymers Dept, Aleea Grigore Ghica Voda 41A, Iasi 700487, Romania in 2019.0, Cited 53.0. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7.

A novel aromatic diamine containing 1,3,4-oxadiazole-substituted triphenylamine (TPA) was successfully synthesized and structurally characterized. Based on this, a series of three aromatic polyimides with high thermal stability were prepared and processed in thin coatings with a grain-like morphology. Their ability to form a dual intramolecular charge transfer complex between TPA and 1,3,4-oxadiazole in the side chain and TPA and phthalimide in the main chain was proven. Both the optical effects and electronic properties were found to be modulated by the competing electron-withdrawing character of 1,3,4-oxadiazole/imide units. The electrochemical investigation suggested their n-type redox capability and electron transporting characteristics, a statement supported by current-voltage measurements of some indium tin oxide/poly(3,4-ethylenedioxythiophene): polystyrene sulfonate/polyimide/eGaIn prototype devices. Thereby, the present polyimides enable the pathway toward alternative n-type materials currently used in optoelectronics devices.

Formula: C7H5NO4. Welcome to talk about 62-23-7, If you have any questions, you can contact Bejan, AE; Constantin, CP; Damaceanu, MD or send Email.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

In 2020 CHEM BIODIVERS published article about MULTIDRUG-RESISTANCE; NATURAL-PRODUCTS; MACROCYCLIC DITERPENES; BIOLOGICAL-ACTIVITY; MODULATION; PLANTS in [Wang, Wang; Wu, Yanli; Li, Chen; Yang, Yueying; Li, Hua; Chen, Lixia] Shenyang Pharmaceut Univ, Wuya Coll Innovat, Key Lab Struct Based Drug Design & Discovery, Minist Educ, Shenyang 110016, Peoples R China; [Li, Hua] Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Pharm, Hubei Key Lab Nat Med Chem & Resource Evaluat, Wuhan 430030, Peoples R China; [Li, Xingzhou] Beijing Inst Pharmacol & Toxicol, Natl Engn Res Ctr Emergency Drug, Beijing 100850, Peoples R China in 2020, Cited 35. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7. Name: 4-Nitrobenzoic acid

Euphorbia factor L-3, a lathyrane diterpenoid extracted from Euphorbia lathyris, was found to display good anti-inflammatory activity with very low cytotoxicity. To find more potent anti-inflammatory drugs, two series of Euphorbia factor L-3 derivatives with fatty and aromatic acids were designed and synthesized. Among them, lathyrane derivative 5n exhibited most potent inhibition on LPS-induced NO production in RAW264.7 cells with no obvious cytotoxicity. To determine the key characteristics of Euphorbia factor L-3 derivatives that contribute to anti-inflammatory activity, we conducted a structure-activity relationship study of these compounds.

Welcome to talk about 62-23-7, If you have any questions, you can contact Wang, W; Wu, YL; Li, C; Yang, YY; Li, XZ; Li, H; Chen, LX or send Email.. Name: 4-Nitrobenzoic acid

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

I found the field of Pharmacology & Pharmacy very interesting. Saw the article Class I/IIb-Selective HDAC Inhibitor Exhibits Oral Bioavailability and Therapeutic Efficacy in Acute Myeloid Leukemia published in 2020.0. Application In Synthesis of 4-Nitrobenzoic acid, Reprint Addresses Gunning, PT (corresponding author), Univ Toronto Mississauga, Dept Chem & Phys Sci, 3359 Mississauga Rd, Mississauga, ON L5L 1C6, Canada.. The CAS is 62-23-7. Through research, I have a further understanding and discovery of 4-Nitrobenzoic acid

The HDAC inhibitor 4-tert-butyl-N-(4-(hydroxycarbamoyl)phenyl)benzamide (AES-350, 51) was identified as a promising preclinical candidate for the treatment of acute myeloid leukemia (AML), an aggressive malignancy with a meagre 24% 5-year survival rate. Through screening of low-molecular-weight analogues derived from the previously discovered novel HDAC inhibitor, AES-135, compound 51 demonstrated greater HDAC isoform selectivity, higher cytotoxicity in MV4-11 cells, an improved therapeutic window, and more efficient absorption through cellular and lipid membranes. Compound 51 also demonstrated improved oral bioavailability compared to SAHA in mouse models. A broad spectrum of experiments, including FACS, ELISA, and Western blotting, were performed to support our hypothesis that 51 dose-dependently triggers apoptosis in AML cells through HDAC inhibition.

Welcome to talk about 62-23-7, If you have any questions, you can contact Shouksmith, AE; Gawel, JM; Nawar, N; Sina, D; Raouf, YS; Bukhari, S; He, LY; Johns, AE; Manaswiyoungkul, P; Olaoye, OO; Cabral, AD; Sedighi, A; de Araujo, ED; Gunning, PT or send Email.. Application In Synthesis of 4-Nitrobenzoic acid

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Sharma, P; Tripathi, A; Tripathi, PN; Sen Singh, S; Singh, SP; Shrivastava, SK in [Sharma, Piyoosh; Tripathi, Avanish; Tripathi, Prabhash Nath; Shrivastava, Sushant Kumar] Banaras Hindu Univ, Indian Inst Technol, Dept Pharmaceut Engn & Technol, Varanasi 221005, Uttar Pradesh, India; [Sen Singh, Saumitra; Singh, Surya Pratap] Banaras Hindu Univ, Fac Sci, Dept Biochem, Varanasi 221005, Uttar Pradesh, India published Novel Molecular Hybrids of N-Benzylpiperidine and 1,3,4-Oxadiazole as Multitargeted Therapeutics to Treat Alzheimer’s Disease in 2019, Cited 80. Computed Properties of C7H5NO4. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7.

Multitargeted hybrids of N-benzylpiperidine and substituted 5-phenyl-1,3,4-oxadiazoles were designed, synthesized, and evaluated against Alzheimer’s disease (AD). Tested compounds exhibited moderate to excellent inhibition against human acetylcholinesterase (hAChE), butyrylcholinesterase (hBChE), and beta-secretase-1 (hBACE-1). The potential leads 6g and 10f exhibited balanced inhibitory profiles against all the targets, with a substantial displacement of propidium iodide from the peripheral anionic site of hAChE. Hybrids 6g and 10f also elicited favorable permeation across the blood -brain barrier and were devoid of neurotoxic liability toward SH-SYSY neuroblastoma cells. Both leads remarkably disassembled A beta aggregation in thioflavin T-based selfand AChE-induced experiments. Compounds 6g and 10f ameliorated scopolamine gamma-induced cognitive dysfunctions in the Ymaze test. The ex vivo studies of rat brain homogenates established the reduced AChE levels and antioxidant activity of both compounds. Compound 6g also elicited noteworthy improvement in A beta-induced cognitive dysfunctions in the Morris water maze test with downregulation in the expression of A beta and BACE-1 proteins corroborated by Western blot and immunohistochemical analysis. The pharmacokinetic study showed excellent oral absorption characteristics of compound 6g. The in silica molecular docking and dynamics simulation studies of lead compounds affirmed their consensual binding interactions with PAS-AChE and aspartate dyad of BACE-1.

Welcome to talk about 62-23-7, If you have any questions, you can contact Sharma, P; Tripathi, A; Tripathi, PN; Sen Singh, S; Singh, SP; Shrivastava, SK or send Email.. Computed Properties of C7H5NO4

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

COA of Formula: C7H5NO4. Hong, JE; Jung, Y; Park, Y; Park, Y in [Hong, Jee Eun; Jung, Yeonghun; Park, Youmie; Park, Yohan] Inje Univ, Coll Pharm, Gimhae 50834, Gyeongnam, South Korea; [Hong, Jee Eun; Jung, Yeonghun; Park, Youmie; Park, Yohan] Inje Univ, Inje Inst Pharmaceut Sci & Res, Gimhae 50834, Gyeongnam, South Korea published Highly Selective Synthesis of Hydrazoarenes from Nitroarenes via Polystyrene-Supported Au-Nanoparticle-Catalyzed Reduction: Application to Azoarenes, Aminoarenes, and 4,4 ‘-Diaminobiaryls in 2020, Cited 48. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7.

A selective synthesis of hydrazoarene from nitroarene and its application are reported. Using polystyrene (PS) resins as solid supports for Au nanoparticles (AuNPs), polystyrene-supported Au nanoparticles (AuNPs@PS) were synthesized and characterized. In the presence of AuNPs@PS (1.0 mol %) as a catalyst, nitroarenes afforded corresponding hydrazoarenes (up to 99%) with high selectivity (up to 100%) under mild reaction conditions (NaBH4, 50% aq. EtOH, and room temperature). Depending on the reaction conditions (the amount of NaBH4, the substituent of nitroarenes, and the sequential addition of HCl), nitroarenes were converted to corresponding azoarenes (up to 95%), aminoarenes (up to 99%), and 4,4’-diaminobiaryls (up to 99%). Our easily recyclable catalytic system using a solid-phase reaction vessel provides an attractive synthetic method in an eco-friendly and sustainable manner.

Welcome to talk about 62-23-7, If you have any questions, you can contact Hong, JE; Jung, Y; Park, Y; Park, Y or send Email.. COA of Formula: C7H5NO4

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem