Month: December 2021

Recently I am researching about II NADH DEHYDROGENASE; DERIVATIVES; OXIDOREDUCTASE; ACTIVATION; INHIBITORS; SERIES, Saw an article supported by the Maurice Wilkins Centre for Molecular Biodiscovery. Computed Properties of C7H5NO4. Published in WILEY-V C H VERLAG GMBH in WEINHEIM ,Authors: Santoso, KT; Brett, MW; Cheung, CY; Cook, GM; Stocker, BL; Timmer, MSM. The CAS is 62-23-7. Through research, I have a further understanding and discovery of 4-Nitrobenzoic acid

Drug-resistant strains of Mycobacterium tuberculosis are on the rise and have resulted in an urgent need to develop new tuberculosis (TB) drugs. Herein, the development of chromonyl-pyrimidines as a new TB drug scaffold is presented. A library of eleven chromonyl-pyrimidines was synthesised, from which lead compound 6-((2-amino-6-methylpyrimidin-4-yl)amino)-3-benzoyl-2-phenyl-4H-chromen-4-one (MIC=36 mu M against M. tuberculosis) was identified. A second-generation library of seven aryl-substituted chromonyl-pyrimidines was then prepared, with six chromonyl-pyrimidines exhibiting an improved M. tuberculosis growth inhibition (MIC=12.5 mu M). From this work, the potential of chromonyl-pyrimidines as therapeutics for TB is demonstrated.

Bye, fridends, I hope you can learn more about C7H5NO4, If you have any questions, you can browse other blog as well. See you lster.. Computed Properties of C7H5NO4

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

An article SkinEthic (TM) HCE Eye Irritation Test: Similar performance demonstrated after long distance shipment and extended storage conditions WOS:000454467300022 published article about HAZARD IDENTIFICATION; CHEMICALS; EIT in [Leblanc, Virginie; Grandidier, Marie-Helene; Cotovio, Jose; Alepee, Nathalie] LOreal Res & Innovat, 1 Ave Eugene Schueller, F-93600 Aulnay Sous Bois, France; [Yokota, Mariko] Cosmos Tech Ctr Co Ltd, NIKKOL Grp, Tokyo, Japan; [Yoshida, Daisuke; Kyoutani, Daiki] Nikoderm Res Inc, NIKKOL Grp, Osaka, Japan; [Adriaens, Els] Adriaens Consulting, Aalter, Belgium in 2019.0, Cited 16.0. SDS of cas: 62-23-7. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7

Assessment of ocular irritation risk is an international regulatory requirement in the safety evaluation of products. In response to this need, L’Oreal developed the SkinEthie Human Corneal Epithelium (HCE) Eye Irritation Test (Err) that has been included in OECD Test Guideline 492. SkinEthic (TM) HCE EIT is able to correctly and reliably identify chemicals not requiring classification versus labelling for eye irritation or serious eye damage according to UN GHS. In an effort to promote its global use, the performance of the method was evaluated after long-distance shipment and compared to European shipment conditions. Results obtained by Cosmos Technical Center (Japan) after extended tissues transit were compared to results obtained in L’Oreal (France). Thirty-nine out of 40 blinded chemicals, representing different functional chemical classes, were consistently classified in both laboratories. The SkinEthic (TM) HCE EIT test method was also evaluated for its performance after extended storage of the tissues. The performance was in agreement with the values reported in OECD TG 492, with an overall accuracy of 87.1% (based on 119 chemicals), sensitivity of 95.5% and specificity of 73.5%. The reliability and relevance of SkinEthic (TM) HCE Err test method after long-distance shipment and extended storage remain in agreement with regulatory validation criteria.

SDS of cas: 62-23-7. Bye, fridends, I hope you can learn more about C7H5NO4, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Name: 4-Nitrobenzoic acid. In 2019 CHEMISTRYSELECT published article about BIOLOGICAL EVALUATION; PHARMACOLOGICAL-ACTIVITIES; INHIBITORS; POTENT; TRIAZOLOTHIADIAZINES; THIENOPYRIMIDINES; 1,2,4-TRIAZOLES; THIADIAZOLES; THIOPHENE in [Settypalli, Triloknadh; Chunduri, Venkata Rao; Kerru, Nagaraju; Nallapaneni, Hari Krishna] Sri Venkateswara Univ, Dept Chem, Tirupati 517502, Andhra Pradesh, India; [Chintha, Venkata Ramaiah; Daggupati, Trinath; Yeguvapalli, Suneetha; Wudayagiri, Rajendra] Sri Venkateswara Univ, Dept Zool, Tirupati 517502, Andhra Pradesh, India in 2019, Cited 55. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7.

In pursuit of neuroprotective and antimicrobial agents, a series of 1,2,4-triazolo[3,4-b]1,3,4-thiadiazole incorporated thieno[2,3-d]pyrimidine derivatives 10 a-l has been designed, synthesized. The final target compounds were screened for neuroprotective, neurotoxic and antibacterial activities. The compounds derived from 4-methylphenyl (10 a) and 4-nitrophenyl (10 c) have showed good neuroprotective activity against H2O2 induced PC12 cell death at respective EC50 values of 10.44, 14.12 mu g/mL. However 10 b and 10 k showed superior neurotoxic effects than rest of the compounds with respective CC50 values of 100.16, 120 mu g/mL. Potent antibacterial activity was shown by 10 f (R=-Me, R-2=-OMe), 10 h (R=-Me, R-2=-Cl) against the four bacterial pathogens such as S.aureus, B.subtilis, E.coli and P.aeruginosa at low minimum inhibitory concentration (MIC) range. Further, in silico docking studies were performed for all the synthesized compounds with C(30) carotenoid dehydrosqualene synthase, Gyrase A and LpxC bacterial proteins. Interestingly, 10 f, 10 h showed good binding affinities with target proteins and these results are in good compliance with the in vitro activity profile data.

Name: 4-Nitrobenzoic acid. Welcome to talk about 62-23-7, If you have any questions, you can contact Settypalli, T; Chunduri, VR; Kerru, N; Nallapaneni, HK; Chintha, VR; Daggupati, T; Yeguvapalli, S; Wudayagiri, R or send Email.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

An article Silica catalyzed one pot synthesis of hybrid thiazolidin-4-one derivatives as anti-tubercular and anti-inflammatory agent by attenuating COX-2 pathway WOS:000479497800001 published article about MOLECULAR DOCKING; STROKE RISK; 1,3,4-THIADIAZOLE; NSAIDS in [Pathak, Prateek; Naumovich, Vladislav; Grishina, Maria; Potemkin, Vladimir] South Ural State Univ, Higher Med & Biol Sch, Lab Modeling Drugs, Tchaikovsky Str 20-A, Chelyabinsk 454008, Russia; [Shukla, Parjanya Kumar; Verma, Amita] Sam Higginbottom Univ Agr Technol & Sci, Fac Hlth Sci, Dept Pharmaceut Sci, Bioorgan & Med Chem Res Lab, Allahabad 211007, Uttar Pradesh, India; [Shukla, Parjanya Kumar] Uttar Pradesh Tech Univ, Krishnarpit Inst Pharm, Allahabad, Uttar Pradesh, India in 2019, Cited 49. Application In Synthesis of 4-Nitrobenzoic acid. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7

A novel series of a hybrid class of hybrid thiazolidin-4-one derivatives were designed and synthesized through one-pot catalytic synthesis. The reaction was catalyzed in the presence of silica-H(2)SO4((+6)). The derivatives computational ADMET profile was calculated. The study shows that most active derivatives have optimal logP, higher anti-inflammatory activity score, and poor metabolism at the sight of P450-3A4 and 2D6. The entire series of derivatives were further evaluated for anti-tubercular (against Mycobacterium tuberculosis H37Rv (Resistant strain)) and anti-inflammatory activity (in-vivo assay using Wistar rat). The result showed that derivatives 4c, 4h, and 4m have significant potency against tested M. tuberculosis. However, derivatives 4i and 4j found significantly active against inflammation. In vitro COX inhibition assay also supported the result in favor of selectivity and efficacy of derivatives. [GRAPHICS] .

Application In Synthesis of 4-Nitrobenzoic acid. Welcome to talk about 62-23-7, If you have any questions, you can contact Pathak, P; Shukla, PK; Naumovich, V; Grishina, M; Potemkin, V; Verma, A or send Email.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Authors Mayhew, AW; Topping, DO; Hamilton, JF in AMER CHEMICAL SOC published article about PREDICTION; SCALE; BEWARE; MODEL; V1.0 in [Mayhew, Alfred W.; Hamilton, Jacqueline F.] Univ York, Dept Chem, Wolfson Atmospher Chem Labs, York YO10 5DD, N Yorkshire, England; [Topping, David O.] Univ Manchester, Manchester M13 9PL, Lancs, England in 2020, Cited 31. SDS of cas: 62-23-7. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7

Electrospray ionization (ESI) is widely used as an ionization source for the analysis of complex mixtures by mass spectrometry. However, different compounds ionize more or less effectively in the ESI source, meaning instrument responses can vary by orders of magnitude, often in hard-to-predict ways. This precludes the use of ESI for quantitative analysis where authentic standards are not available. Relative ionization efficiency (RIE) scales have been proposed as a route to predict the response of compounds in ESL In this work, a scale of RIEs was constructed for 51 carboxylic acids, spanning a wide range of additional functionalities, to produce a model for predicting the RIE of unknown compounds. While using a limited number of compounds, we explore the usefulness of building a predictor using popular supervised regression techniques, encoding the compounds as combinations of different structural features using a range of common fingerprints. It was found that Bayesian ridge regression gives the best predictive model, encoding compounds using features designed for activity coefficient models. This produced a predictive model with an R-2 score of 0.62 and a root-mean-square error (RMSE) of 0.362. Such scores are comparable to those obtained in previous studies but without the requirement to first measure or predict the physical properties of the compounds, potentially reducing the time required to make predictions.

SDS of cas: 62-23-7. Bye, fridends, I hope you can learn more about C7H5NO4, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Recently I am researching about CATALYZED CARBONYLATIVE SYNTHESIS; FACILE SYNTHESIS; CYANAMIDES; INHIBITORS; POTENT; TRIPHENYLPHOSPHINE; ISOTHIOCYANATES; QUINAZOLINONES; TRANSFORMATION; LEUCETTINES, Saw an article supported by the Chiang Mai University; Thailand Research Fund through the Royal Golden Jubilee Ph.D. ProgramThailand Research Fund (TRF) [PHD/0023/2559]; Center of Excellence for Innovation in Chemistry (PERCH-CIC), Office of the Higher Education Commission, Ministry of Education, Thailand. Published in GEORG THIEME VERLAG KG in STUTTGART ,Authors: Phakhodee, W; Yamano, D; Pattarawarapan, M. The CAS is 62-23-7. Through research, I have a further understanding and discovery of 4-Nitrobenzoic acid. Formula: C7H5NO4

A convenient ultrasound-assisted one-pot synthesis of N -acylcyanamides starting from readily available carboxylic acids and sodium cyanamide has been developed. Upon activation in the presence of trichloroisocyanuric acid (TCCA) and triphenylphosphine, a range of carboxylic acids was converted into N -acylcyanamides in good to excellent yields within 10 minutes at room temperature without base. Remarkably, N -acyl-substituted imidazolones were readily accessible through guanylation-cyclization of the in situ generated N -acylcyanamides.

Formula: C7H5NO4. Bye, fridends, I hope you can learn more about C7H5NO4, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Safety of 4-Nitrobenzoic acid. In 2019.0 ACS OMEGA published article about STYRYL-LACTONES in [Kotammagari, Tharun K.; Paul, Sayantan; Bhattacharya, Asish K.] Natl Chem Lab, CSIR, Div Organ Chem, Dr Homi Bhabha Rd, Pune 411008, Maharashtra, India; [Kotammagari, Tharun K.; Paul, Sayantan; Bhattacharya, Asish K.] Natl Chem Lab, CSIR, Acad Sci & Innovat Res AcSIR, Dr Homi Bhabha Rd, Pune 411008, Maharashtra, India in 2019.0, Cited 26.0. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7.

(-)-5-Hydroxygoniothalamin, (-)-5-acetylgoniothalamin, and (+)-5-hydroxygoniothalamin, isolated from the Goniothalamus genus, are synthesized from triacetyl-O-D-glucal by employing the Ferrier reaction, Mitsunobu reaction, and Jones oxidation as key steps. The synthetic procedure also yields the epimers of (-)-5-hydroxygoniothalamin and (+)-5-hydroxygoniothalamin employing acid-mediated transition-metal-free epimerization at C-5 of styryllactones. Further studies reveal that the epimerization is facilitated by the phenyl group present on the styryllactones. Also, depending on the dihydroxylation reaction conditions, various analogues of saturated styryllactones are synthesized utilizing oxa-Michael reaction conditions.

Safety of 4-Nitrobenzoic acid. Bye, fridends, I hope you can learn more about C7H5NO4, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Authors Lu, WC; Wang, J; Li, Y; Tao, HR; Xiong, H; Lian, FL; Gao, J; Ma, HN; Lu, T; Zhang, D; Ye, XQ; Ding, H; Yue, LY; Zhang, YY; Tang, HY; Zhang, NX; Yang, YX; Jiang, HL; Chen, KX; Zhou, B; Luo, C in ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER published article about PROTEIN S-PALMITOYLATION; HIPPO PATHWAY; YAP; LIGAND; CANCER; MAP in [Lu, Wenchao; Wang, Jun; Tao, Hongru; Ma, Hongna; Lu, Tian; Zhang, Dan; Ye, Xiaoqing; Ding, Hong; Yue, Liyan; Zhang, Yuanyuan; Jiang, Hualiang; Chen, Kaixian; Luo, Cheng] Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, 555 Zuchongzhi Rd, Shanghai 201203, Peoples R China; [Lu, Wenchao; Li, Yong; Tang, Huanyu; Yang, Yaxi; Jiang, Hualiang; Chen, Kaixian; Zhou, Bing; Luo, Cheng] Univ Chinese Acad Sci, 19 Yuquan Rd, Beijing 100049, Peoples R China; [Li, Yong; Xiong, Huan; Tang, Huanyu; Yang, Yaxi; Zhou, Bing] Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Dept Med Chem, 555 Zuchongzhi Rd, Shanghai 201203, Peoples R China; [Wang, Jun; Lu, Tian] Nanjing Univ Chinese Med, Jiangsu Key Lab High Technol Res TCM Formulae, 138 Xianlin Rd, Nanjing 210023, Jiangsu, Peoples R China; [Tao, Hongru] Shanghai Univ, Coll Sci, Dept Chem, 99 Shangda Rd, Shanghai 200444, Peoples R China; [Lian, Fulin; Gao, Jing; Zhang, Naixia] Chinese Acad Sci, Shanghai Inst Mat Med, Dept Analyt Chem, 555 Zuchongzhi Rd, Shanghai 201203, Peoples R China; [Gao, Jing] Chinese Acad Sci, Shanghai Inst Mat Med, CAS Key Lab Receptor Res, 555 Zuchongzhi Rd, Shanghai 201203, Peoples R China; [Ma, Hongna] Guiyang Univ Tradit Chinese Med, Dept Pharm, South Dong Qing Rd, Guiyang 550025, Guizhou, Peoples R China; [Zhang, Dan] Guizhou Univ, Sch Pharmaceut Sci, Key Lab Guizhou Fermentat Engn & Biomed, Guiyang 550025, Guizhou, Peoples R China; [Ye, Xiaoqing] Zhejiang Sci Tech Univ, Coll Life Sci, 928 2 St, Hangzhou 310018, Zhejiang, Peoples R China; [Chen, Kaixian; Luo, Cheng] Pilot Natl Lab Marine Sci & Technol Qingdao, Open Studio Druggabil Res Marine Nat Prod, 1 Wenhai Rd, Qingdao 266237, Shandong, Peoples R China; [Lu, Wenchao] Dana Farber Canc Inst, Dept Canc Biol, Boston, MA 02215 USA in 2019.0, Cited 48.0. Product Details of 62-23-7. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7

Transcriptional enhancer associated domain family members (TEADs) are the most important downstream effectors that play the pivotal role in the development, regeneration and tissue homeostasis. Recent biochemical studies have demonstrated that TEAD5 could undergo autopalmitoylation that is indispensable for its function making the lipid-binding pocket an attractive target for chemical intervention. Herein, through structure-based virtual screen and rational medicinal chemistry optimization, we identified DC-TEADin02 as the most potent, selective, covalent TEAD autopalmitoylation inhibitor with the IC50 value of 197 +/- 19 nM while it showed minimal effect on TEAD-YAP interaction. Further biochemical counter-screens demonstrate the specific thiol reactivity and selectivity of DC-TEADin02 over the kinase family, lipid-binding proteins and epigenetic targets. Notably, DC-TEADin02 inhibited TEADs transcription activity leading to downregulation of YAP-related downstream gene expression. Taken together, our findings proved the validity of modulating transcriptional output in the Hippo signaling pathway through irreversible chemical interventions of TEAD5 autopalmitoylation activity, which may serve as a qualified chemical tool for TEADs palmitoylation-related studies in the future. (C) 2019 Elsevier Masson SAS. All rights reserved.

Welcome to talk about 62-23-7, If you have any questions, you can contact Lu, WC; Wang, J; Li, Y; Tao, HR; Xiong, H; Lian, FL; Gao, J; Ma, HN; Lu, T; Zhang, D; Ye, XQ; Ding, H; Yue, LY; Zhang, YY; Tang, HY; Zhang, NX; Yang, YX; Jiang, HL; Chen, KX; Zhou, B; Luo, C or send Email.. Product Details of 62-23-7

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Product Details of 62-23-7. I found the field of Pharmacology & Pharmacy very interesting. Saw the article Synthesis and anticancer evaluation of new lipophilic 1,2,4 and 1,3,4-oxadiazoles published in 2019.0, Reprint Addresses Couri, MRC (corresponding author), Univ Fed Juiz de Fora, Dept Quim, ICE, Campus Martelo, BR-36036330 Juiz De Fora, MG, Brazil.. The CAS is 62-23-7. Through research, I have a further understanding and discovery of 4-Nitrobenzoic acid.

A series of1,2,4- and 1,3,4-oxadiazole derivatives were synthesized and evaluated for their anticancer activity. Halogenated 1,2,4-oxadiazoles were obtained from benzonitrile and coupled either lipophilic amines or with aminoalcohols. Lipophilic 1,3,4-oxadiazole derivatives were obtained through the Mannich reactions between 5-(aryl)-1,3,4-oxadiazole-2-thiol and alkylated or acylated amines. The in vitro cytotoxic effects were evaluated against 4T1- mammary carcinoma and CT26 – colon cancer cells. The best results were obtained for the 1,3,4-oxadiazole coupled to alkylated piperazine with 10-14 carbon chain moiety, with IC50 values ranging from 1.6 to 3.55 mu M for the 4T1 cell line, and from 1.6 to 3.9 mu M for the CT26.WT cell line, and selectivity index up to 19. The most potent compounds were investigated with AnnexinV and PI staining as indicative of apoptosis induction. (C) 2019 Published by Elsevier Masson SAS.

Product Details of 62-23-7. Bye, fridends, I hope you can learn more about C7H5NO4, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Authors Wen, JC; Chennamadhavuni, D; Morel, SR; Hadden, MK in AMER CHEMICAL SOC published article about SMOOTHENED MUTATIONS; ACQUIRED-RESISTANCE; PATHWAY INHIBITOR; ANTIFUNGAL; VISMODEGIB in [Wen, Jiachen; Chennamadhavuni, Divya; Morel, Shana R.; Hadden, M. Kyle] Univ Connecticut, Dept Pharmaceut Sci, 69 North Eagleville Rd,Unit 3092, Storrs, CT 06029 USA in 2019, Cited 25. Computed Properties of C7H5NO4. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7

We conducted a structure-activity relationship study to explore simplified analogues of the itraconazole (ITZ) scaffold for their ability to inhibit the hedgehog (Hh) signaling pathway. These analogues were based on exploring the effects of chemical modifications to the linker and triazolone/side chain region of ITZ. Analogue 11 was identified as the most potent compound in our first generation, with an IC50 value of 81 nM in a murine Hh-dependent basal cell carcinoma. Metabolic identification studies led us to identify truncated piperazine (26) as the major metabolite in human liver microsomes (HLMs) and an improved Hh pathway inhibitor (IC50 = 22 nM). This work verifies that continued truncation of the ITZ scaffold is a practical method to maintain potent anti-Hh activity while also reducing the molecular weight for the ITZ scaffold and achieving improved pharmacokinetic properties.

Welcome to talk about 62-23-7, If you have any questions, you can contact Wen, JC; Chennamadhavuni, D; Morel, SR; Hadden, MK or send Email.. Computed Properties of C7H5NO4

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem