In 2019 CHEMISTRYSELECT published article about BIOLOGICAL EVALUATION; PHARMACOLOGICAL-ACTIVITIES; INHIBITORS; POTENT; TRIAZOLOTHIADIAZINES; THIENOPYRIMIDINES; 1,2,4-TRIAZOLES; THIADIAZOLES; THIOPHENE in [Settypalli, Triloknadh; Chunduri, Venkata Rao; Kerru, Nagaraju; Nallapaneni, Hari Krishna] Sri Venkateswara Univ, Dept Chem, Tirupati 517502, Andhra Pradesh, India; [Chintha, Venkata Ramaiah; Daggupati, Trinath; Yeguvapalli, Suneetha; Wudayagiri, Rajendra] Sri Venkateswara Univ, Dept Zool, Tirupati 517502, Andhra Pradesh, India in 2019, Cited 55. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7. Recommanded Product: 4-Nitrobenzoic acid
In pursuit of neuroprotective and antimicrobial agents, a series of 1,2,4-triazolo[3,4-b]1,3,4-thiadiazole incorporated thieno[2,3-d]pyrimidine derivatives 10 a-l has been designed, synthesized. The final target compounds were screened for neuroprotective, neurotoxic and antibacterial activities. The compounds derived from 4-methylphenyl (10 a) and 4-nitrophenyl (10 c) have showed good neuroprotective activity against H2O2 induced PC12 cell death at respective EC50 values of 10.44, 14.12 mu g/mL. However 10 b and 10 k showed superior neurotoxic effects than rest of the compounds with respective CC50 values of 100.16, 120 mu g/mL. Potent antibacterial activity was shown by 10 f (R=-Me, R-2=-OMe), 10 h (R=-Me, R-2=-Cl) against the four bacterial pathogens such as S.aureus, B.subtilis, E.coli and P.aeruginosa at low minimum inhibitory concentration (MIC) range. Further, in silico docking studies were performed for all the synthesized compounds with C(30) carotenoid dehydrosqualene synthase, Gyrase A and LpxC bacterial proteins. Interestingly, 10 f, 10 h showed good binding affinities with target proteins and these results are in good compliance with the in vitro activity profile data.
Welcome to talk about 62-23-7, If you have any questions, you can contact Settypalli, T; Chunduri, VR; Kerru, N; Nallapaneni, HK; Chintha, VR; Daggupati, T; Yeguvapalli, S; Wudayagiri, R or send Email.. Recommanded Product: 4-Nitrobenzoic acid
Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem