Month: January 2022

An article Integrated continuous flow/batch protocol for the photoreduction of ortho-methyl phenyl ketones using water as the hydrogen source WOS:000471669100004 published article about CONTINUOUS-FLOW SYNTHESIS; O-QUINODIMETHANES; ALDEHYDES; BENZYLATION; REDUCTION; CHEMISTRY; EFFICIENT; CATALYST in [Aand, Dnyaneshwar; Mahajan, Bhushan; Pabbaraja, Srihari; Singh, Ajay K.] Indian Inst Chem Technol, CSIR, Dept Organ Synth & Proc Chem, Hyderabad, India in 2019, Cited 41. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7. Computed Properties of C7H5NO4

Direct utilization of the abundant hydrogen in water for the transfer hydrogenation reaction (THR) is a very attractive and challenging research area. Herein, we report the first integrated photo-transfer hydrogenation reaction (PTHR) platform for the synthesis of benzhydrol derivatives (26 examples, 33-89% yields) with water as a green reducing agent. This transformation is time and labor-efficient, catalyst-free, and economical and utilizes readily available hydrocarbon(s) (o-methyl phenyl ketones) as starting materials.

Computed Properties of C7H5NO4. Bye, fridends, I hope you can learn more about C7H5NO4, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

In 2020 MED CHEM RES published article about BIOLOGICAL EVALUATION; MOLECULAR DOCKING; ELLIPTICINE DERIVATIVES; AMIDE DERIVATIVES; POTENT; INHIBITORS; ANALOGS; DISCOVERY; BINDING; SERIES in [Kala, Pruthu; Khasim Sharif, Syed; Ramachandran, Dittakavi] Acharya Nagarjuna Univ, Dept Chem, Nagarjuna Nagar 522510, Andhra Pradesh, India; [Murali Krishna, CH.] Adikavi Nannaya Univ, Dept Chem, Rajamahendravaram 533296, Andhra Pradesh, India in 2020, Cited 57. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7. Product Details of 62-23-7

A library of 1,2,4-oxadiazole functionalized quinoline derivatives (13a-j) were synthesized and their structures were confirmed by H-1 NMR, (CNMR)-C-13 and Mass Spectral analysis. Further, these compounds were evaluated for their anticancer activity against four human cancer cell lines, namely MCF-7 (breast), A549 (lung), DU-145 (prostate) and MDA MB-231 (breast) using Etoposide as the positive control. Most of these derivatives exhibited more potent activity towards the four cancer cell lines compared to Etoposide. Amongst all the compounds tested, compounds 13b, 13c, 13h, 13i and 13j exhibited promising activity. Further of these compounds 13b, 13i and 13j exhibited excellent activity, when compared with Etoposide.

Welcome to talk about 62-23-7, If you have any questions, you can contact Kala, P; Sharif, SK; Krishna, CM; Ramachandran, D or send Email.. Product Details of 62-23-7

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

An article Choline Chloride/Urea as an Eco-Friendly Deep Eutectic Solvent for TCT-Mediated Amide Coupling at Room Temperature WOS:000467344100001 published article about CARBOXYLIC-ACIDS; BOND FORMATION; IONIC LIQUIDS; 2,4,6-TRICHLORO-1,3,5-TRIAZINE TCT; OXIDATIVE AMIDATION; CYANURIC CHLORIDE; ACTIVATION; ALDEHYDES; PHENOLS; REAGENT in [Salimiyan, Kimiya] Persian Gulf Univ, Fac Sci, Dept Chem, Bushehr 75169, Iran; [Saberi, Dariush] Persian Gulf Univ, Marine Chem Dept, Fac Marine Sci & Technol, Bushehr 75169, Iran; [Saberi, Dariush] Persian Gulf Univ, Fisheries & Aquaculture Dept, Fac Agr & Nat Resources, Bushehr 75169, Iran in 2019, Cited 59. Quality Control of 4-Nitrobenzoic acid. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7

A desirable alternative to organic solvents, very cheap, non-toxic and biodegradable deep eutectic solvent (DES) based on choline chloride and urea was introduced for 2,4,6-trichloro triazine mediated amide bond formation between carboxylic acids and amines at room temperature. Sub-stoichiometric amount of TCT was used as a cheap and readily available C-O activating reagent. Various derivatives of amines were coupled with carboxylic acids, via triacylated triazine intermediate, resulting the reaction of acids with TCT, and the corresponding amides were obtained in moderate to good yields.

Quality Control of 4-Nitrobenzoic acid. Welcome to talk about 62-23-7, If you have any questions, you can contact Salimiyan, K; Saberi, D or send Email.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

An article One-pot and regioselective synthesis of polysubstituted 3,4-dihydroquinazolines and 4,5-dihydro-3H-1,4-benzodiazepin-3-ones by sequential Ugi/Staudinger/aza-Wittig reaction WOS:000458708500011 published article about FACILE SYNTHESIS; RECEPTOR ANTAGONIST; EFFICIENT SYNTHESIS; COUPLING REACTION; DERIVATIVES; CYCLIZATION; ACCESS; SERIES; ROUTE; CELLS in [Xiong, Jun; Wei, Xiao; Wan, Yu-Chen; Ding, Ming-Wu] Cent China Normal Univ, Key Lab Pesticide & Chem Biol, Minist Educ, Hubei Int Sci & Technol Cooperat Base Pesticide &, Wuhan, Hubei, Peoples R China; [Xiong, Jun] Hubei Univ Sci & Technol, Coll Pharm, Xianning 437100, Hubei, Peoples R China in 2019.0, Cited 59.0. HPLC of Formula: C7H5NO4. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7

An efficient one-pot and regioselective synthesis of 3,4-dihydroquinazolines and 4,5-dihydro-3H-1,4-benzodiazepin-3-ones by Ugi/Staudinger/aza-Wittig sequence has been developed. The Ugi reactions of 2-azidobenzylamines, aldehydes, acids (or alpha-keto acids) and isocyanides produced the azide intermediates, which were then treated with tributylphosphine or triphenylphosphine to give poly-substituted 3,4-dihydroquinazolines or 4,5-dihydro-3H-1,4-benzodiazepin-3-ones in moderate to good yields by tandem Standinger/aza-Wittig reactions. (C) 2019 Elsevier Ltd. All rights reserved.

HPLC of Formula: C7H5NO4. Welcome to talk about 62-23-7, If you have any questions, you can contact Xiong, J; Wei, X; Wan, YC; Ding, MW or send Email.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

I found the field of Chemistry very interesting. Saw the article Isothiourea-Catalysed Regioselective Acylative Kinetic Resolution of Axially Chiral Biaryl Diols published in 2019.0. COA of Formula: C7H5NO4, Reprint Addresses Smith, AD (corresponding author), Univ St Andrews, Sch Chem, EaStCHEM, St Andrews KY16 9ST, Fife, Scotland.. The CAS is 62-23-7. Through research, I have a further understanding and discovery of 4-Nitrobenzoic acid

An operationally simple isothiourea-catalysed acylative kinetic resolution of unprotected 1,1 ‘-biaryl-2,2 ‘-diol derivatives has been developed to allow access to axially chiral compounds in highly enantioenriched form (s values up to 190). Investigation of the reaction scope and limitations provided three key observations: i) the diol motif of the substrate was essential for good conversion and high s values; ii) the use of an alpha,alpha-disubstituted mixed anhydride (2,2-diphenylacetic pivalic anhydride) was critical to minimize diacylation and give high selectivity; iii) the presence of substituents in the 3,3 ‘-positions of the diol hindered effective acylation. This final observation was exploited for the highly regioselective acylative kinetic resolution of unsymmetrical biaryl diol substrates bearing a single 3-substituent. Based on the key observations identified, acylation transition state models have been proposed to explain the atropselectivity of this kinetic resolution.

COA of Formula: C7H5NO4. Welcome to talk about 62-23-7, If you have any questions, you can contact Qu, S; Greenhalgh, MD; Smith, AD or send Email.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

An article Novel N-Acyl-1H-imidazole-1-carbothioamides: Design, Synthesis, Biological and Computational Studies WOS:000514482400001 published article about ANTIOXIDANT ACTIVITIES; ANTIMICROBIAL ACTIVITY; THIOUREA DERIVATIVES; OXIDATIVE STRESS; L. in [Aziz, Hamid; Saeed, Aamer] Quaid I Azam Univ, Dept Chem, Islamabad 45320, Pakistan; [Khan, Muhammad Aslam; Afridi, Shakeeb] Quaid I Azam Univ, Dept Biotechnol, Islamabad 45320, Pakistan; [Jabeen, Farukh] Laurentian Univ, Dept Biol, 935 Ramsey Lake Rd, Sudbury, ON P3E 2C6, Canada; [Jabeen, Farukh] Computat Sci Res & Dev Org, 1401,2485 Hurontraio St, Mississauga, ON L5A 2G6, Canada; [Ashfaq-ur-Rehman] Abdul Wali Khan Univ, Dept Biochem, Shankar Campus, Mardan 23200, Khyber Pukhtoon, Pakistan; [Ashfaq-ur-Rehman] Shanghai Jiao Tong Univ, Dept Bioinformat & Biostat, 800 Dongchuan Rd, Shanghai 200240, Peoples R China; [Hashim, Muhammad] Quaid I Azam Univ, Dept Biochem, Islamabad 45320, Pakistan in 2020, Cited 47. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7. HPLC of Formula: C7H5NO4

The present study reports the convenient synthesis, spectroscopic characterization, bio-assays and computational evaluation of a novel series of N-acyl-1H-imidazole-1-carbothioamides. The screened derivatives displayed excellent antioxidant activity, moderate antibacterial and antifungal potential. The screened derivatives were found to be highly biocompatible against hRBCs. Molecular docking ascertained the mechanism and mode of action towards the molecular target delineating that ligands and complexes were stabilized at the active site by electrostatic and hydrophobic forces in accordance to the corresponding experimental results. Docking simulation provided additional information about the possibilities of inhibitory potential of the compounds against RNA. Computational evaluation predicted that N-acyl-1H-imidazole-1-carbothioamides 5c and 5g can serve as potential surrogates for hit to lead generation and design of novel antioxidant and antibacterial agents.

HPLC of Formula: C7H5NO4. Bye, fridends, I hope you can learn more about C7H5NO4, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

In 2019.0 J AM CHEM SOC published article about RADIOLABELED COMPOUNDS; TERMINAL ALKYNES; H BONDS; CARBOXYLATION; DISCOVERY; ACID; DECARBOXYLATION; CHEMISTRY in [Destro, Gianluca; Loreau, Olivier; Marcon, Elodie; Taran, Frederic; Audisio, Davide] Univ Paris Saclay, CEA, DRF, SCBM,JOLIOT, F-91191 Gif Sur Yvette, France; [Cantat, Thibault] Univ Paris Saclay, CNRS, CEA, NIMBE, F-91191 Gif Sur Yvette, France in 2019.0, Cited 38.0. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7. Formula: C7H5NO4

A copper-catalyzed procedure enabling dynamic carbon isotope exchange is described. Utilizing the universal precursor [C-14]CO2, this protocol allows to insert, in one single step, the desired carbon tag into carboxylic acids with no need of structural modifications. Reducing synthetic costs and limiting the generation of radioactive waste, this procedure will facilitate the access to carboxylic acids containing drugs and accelerate early C-14-based ADME studies supporting drug development.

Formula: C7H5NO4. Welcome to talk about 62-23-7, If you have any questions, you can contact Destro, G; Loreau, O; Marcon, E; Taran, F; Cantat, T; Audisio, D or send Email.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Product Details of 62-23-7. Settypalli, T; Chunduri, VR; Kerru, N; Nallapaneni, HK; Chintha, VR; Daggupati, T; Yeguvapalli, S; Wudayagiri, R in [Settypalli, Triloknadh; Chunduri, Venkata Rao; Kerru, Nagaraju; Nallapaneni, Hari Krishna] Sri Venkateswara Univ, Dept Chem, Tirupati 517502, Andhra Pradesh, India; [Chintha, Venkata Ramaiah; Daggupati, Trinath; Yeguvapalli, Suneetha; Wudayagiri, Rajendra] Sri Venkateswara Univ, Dept Zool, Tirupati 517502, Andhra Pradesh, India published Design, Synthesis, Neuroprotective and Antibacterial Activities of 1,2,4-Triazolo[3,4-b]1,3,4-thiadiazole Linked Thieno[2,3-d]pyrimidine Derivatives and In Silico Docking Studies in 2019, Cited 55. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7.

In pursuit of neuroprotective and antimicrobial agents, a series of 1,2,4-triazolo[3,4-b]1,3,4-thiadiazole incorporated thieno[2,3-d]pyrimidine derivatives 10 a-l has been designed, synthesized. The final target compounds were screened for neuroprotective, neurotoxic and antibacterial activities. The compounds derived from 4-methylphenyl (10 a) and 4-nitrophenyl (10 c) have showed good neuroprotective activity against H2O2 induced PC12 cell death at respective EC50 values of 10.44, 14.12 mu g/mL. However 10 b and 10 k showed superior neurotoxic effects than rest of the compounds with respective CC50 values of 100.16, 120 mu g/mL. Potent antibacterial activity was shown by 10 f (R=-Me, R-2=-OMe), 10 h (R=-Me, R-2=-Cl) against the four bacterial pathogens such as S.aureus, B.subtilis, E.coli and P.aeruginosa at low minimum inhibitory concentration (MIC) range. Further, in silico docking studies were performed for all the synthesized compounds with C(30) carotenoid dehydrosqualene synthase, Gyrase A and LpxC bacterial proteins. Interestingly, 10 f, 10 h showed good binding affinities with target proteins and these results are in good compliance with the in vitro activity profile data.

Product Details of 62-23-7. Welcome to talk about 62-23-7, If you have any questions, you can contact Settypalli, T; Chunduri, VR; Kerru, N; Nallapaneni, HK; Chintha, VR; Daggupati, T; Yeguvapalli, S; Wudayagiri, R or send Email.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

I found the field of Chemistry very interesting. Saw the article Organocatalytic Asymmetric Domino Oxa-Michael-Mannich-[1,3]-Amino Rearrangement Reaction of N-Tosylsalicylimines to alpha,beta-Unsaturated Aldehydes by Diarylprolinol Silyl Ethers published in 2020.0. Computed Properties of C7H5NO4, Reprint Addresses Chen, F (corresponding author), Fudan Univ, Dept Chem, Shanghai 200433, Peoples R China.; Chen, F (corresponding author), Zhejiang Univ Technol, Inst Pharmaceut Sci & Technol, 18 Chao Wang Rd, Hangzhou 310014, Peoples R China.. The CAS is 62-23-7. Through research, I have a further understanding and discovery of 4-Nitrobenzoic acid

An organocatalytic asymmetric enantioselective domino oxa-Michael-Mannich-[1,3]-amino rearrangement reaction of N-tosylsalicylimines with a wide range of alpha,beta-unsaturated aldehydes utilizing diarylprolinol silyl ether catalysis is described. The catalytic reactions proceed with excellent enantioselectivity (up to 99% ee) to produce the corresponding chair N-tosylimines-chromenes with a yield of up to 99%, tolerating a range of functional groups. This methodology offers a new method with great potential to further extend the synthetic power and versatility of chiral aminocatalysis.

Bye, fridends, I hope you can learn more about C7H5NO4, If you have any questions, you can browse other blog as well. See you lster.. Computed Properties of C7H5NO4

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

SDS of cas: 62-23-7. Shen, HM; Liu, L; Qi, B; Hu, MY; Ye, HL; She, YB in [Shen, Hai-Min; Liu, Lei; Qi, Bei; Hu, Meng-Yun; Ye, Hong-Liang; She, Yuan-Bin] Zhejiang Univ Technol, Coll Chem Engn, State Key Lab Breeding Base Green Chem Synth Tech, Hangzhou 310014, Peoples R China published Efficient and selective oxidation of secondary benzylic C-H bonds to ketones with O-2 catalyzed by metalloporphyrins under solvent-free and additive-free conditions in 2020.0, Cited 75.0. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7.

Non-solvent and non-additive oxidation of secondary benzylic C-H bonds to aromatic ketones utilizing simple metalloporphyrins as catalysts and O-2 was investigated systematically. Based on systematical studies on reaction parameters, such as the structures of porphyrins, the types of central metals, the amount of catalyst, the pressure of oxygen, and the temperature, most aromatics with secondary benzylic C-H had been converted efficiently and selectively to their corresponding aromatic ketones catalyzed by the optimized metalloporphyrin catalyst T(2,3,6-triCl)PPCo. And the selectivity towards aromatic ketones reached up to 80 %-95 % with acceptable conversions in lower catalyst-loading (2.4 x 10(-3)%, mol/mol). The highest selectivity was achieved for substrate 1,2,3,4-tetrahydronaphthalene with the selectivity of 95.0 % in the conversion of 46.3 %. The superior catalytic performance of T(2,3,6-triCl)PPCo could be mainly ascribed to its excellent plane structure, superior ability for electron transfer and low positive charge around the central metal. All of above properties promoted the formation of catalytic active species high-valence cobalt-oxo complexes, and facilitated the approach of substrates to the catalytic active centers. This work presented an optimized balance among higher selectivity, milder conditions, lower catalyst-loading, and simpler catalysts compared with current documents, which was not only an efficient, practical and significant strategy to functionalize the widely available aromatics possessing secondary benzylic C-H with high efficiency and selectivity under milder conditions, but also an important instance in the effective functionalization and utilization of other C-H bonds employing optimized catalytic systems based on metalloporphyrins.

Welcome to talk about 62-23-7, If you have any questions, you can contact Shen, HM; Liu, L; Qi, B; Hu, MY; Ye, HL; She, YB or send Email.. SDS of cas: 62-23-7

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem