Recently I am researching about CROSS-COUPLINGS; ENANTIOSELECTIVE ADDITION; ESTERIFICATION; ACTIVATION; CONVERSION; REAGENTS; ALKENES, Saw an article supported by the National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21931010]; National Key Research and Development Program of China [2017YFA0207302]; Program for Changjiang Scholars and Innovative Research Team in University of the Ministry of Education, China. Published in SCIENCE PRESS in BEIJING ,Authors: Chen, H; Chen, DH; Huang, PQ. The CAS is 62-23-7. Through research, I have a further understanding and discovery of 4-Nitrobenzoic acid. Formula: C7H5NO4
N-Acylpyrrole-type amides are a class of versatile building blocks in asymmetric synthesis. We report that by employing Ni(COD)(2)/2,2 ‘-bipyridine (5 mol%) catalytic system, the direct, catalytic alcoholysis of N-acylpyrrole-type aromatic and aliphatic amides with both primary and secondary alcohols can be achieved efficiently under very mild conditions (rt, 1 h) even at gram scale. By increasing the catalyst loading to 10 mol%, prolonging reaction time (18 h), and/or elevating reaction temperature to 50 degrees C/80 degrees C, the reaction could be extended to both complex and hindered N-acylpyrroles as well as to N-acylpyrazoles, Nacylindoles, and to other (functionalized) primary and secondary alcohols. In all cases, only 1.5 equiv. of alcohol were used. The value of the method has been demonstrated by the racemization-free, catalytic alcoholysis of chiral amides yielded from other asymmetric methodologies.
Formula: C7H5NO4. About 4-Nitrobenzoic acid, If you have any questions, you can contact Chen, H; Chen, DH; Huang, PQ or concate me.
Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem