In 2020.0 EUR J MED CHEM published article about STEREOSELECTIVE TOTAL-SYNTHESIS; GENERAL DEFINITION; EFFICIENT in [Benedekovic, Goran; Popsavin, Mirjana; Kovacevic, Ivana; Rodic, Marko; Popsavin, Velimir] Univ Novi Sad, Fac Sci, Dept Chem Biochem & Environm Protect, Trg Dositeja Obradovica 3, Novi Sad, Serbia; [Kojic, Vesna] Univ Novi Sad, Fac Med, Oncol Inst Vojvodina, Put Dr Goldmana 4, Sremska Kamenica 21204, Serbia; [Popsavin, Velimir] Serbian Acad Arts & Sci, Knez Mihajlova 35, Belgrade 11000, Serbia in 2020.0, Cited 28.0. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7. Safety of 4-Nitrobenzoic acid
A new, modified total synthesis of (-)-cleistenolide (1) and sixteen new analogues or derivatives was achieved starting from commercially available 1,2-O-isopropylidene-alpha-D-glucofuranose. The synthesis of 1 proceeds in six steps and 67% overall yield, using single-carbon atom degradation of a protected chiral precursor, (Z)-selective Wittig olefination, and acid catalyzed delta-lactonization. A new Lewis acid promoted procedure for one-pot O-debenzylation/O-acylation has been developed to complete the synthesis of natural product 1 and selected analogues. The synthesized compounds were tested in vitro to evaluate their cytotoxicity against K562, HL-60, Jurkat, Raji, MCF-7, MDA-MB 231, HeLa, A549, and MRC-5 cell lines. All (-)-cleistenolide analogues exhibited significantly higher cytotoxicity than lead 1 against the majority of cell lines tested. Most of the synthesized compounds are more active than doxorubicin on at least one malignant cell line, but were almost completely inactive against normal MRC-5 cells. The structural features of the tested compounds responsible for their antiproliferative activity have been identified by preliminary SAR analysis. (C) 2020 Elsevier Masson SAS. All rights reserved.
Safety of 4-Nitrobenzoic acid. About 4-Nitrobenzoic acid, If you have any questions, you can contact Benedekovic, G; Popsavin, M; Kovacevic, I; Kojic, V; Rodic, M; Popsavin, V or concate me.
Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem