Month: February 2022

An article Ruthenium-Catalyzed Regioselective Direct Ortho-Acyloxylation of Azoarenes with Carboxylic Acids via C-H Bond Activation WOS:000458273900018 published article about AROMATIC AZO-COMPOUNDS; DECARBOXYLATIVE ORTHO-ACYLATION; C(SP(2))-H BONDS; DIRECT ACCESS; AZOBENZENES; ACETOXYLATION; HYDROXYLATION; OXYGENATIONS; ARYLATION; ANILINES in [Kianmehr, Ebrahim; Nasab, Sepideh Bahrami] Univ Tehran, Sch Chem, Coll Sci, Tehran, Iran in 2019, Cited 73. Formula: C7H5NO4. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7

A Ru-II-catalyzed highly regioselective C-H acyloxylation of azoarenes with inexpensive alkyl and aryl carboxylic acids as an acyloxylation agent is described. The reaction demonstrates a broad substrate scope and good functional group tolerance. This method provides a facile procedure to synthesize ortho-acyloxylated azoarene derivatives.

Bye, fridends, I hope you can learn more about C7H5NO4, If you have any questions, you can browse other blog as well. See you lster.. Formula: C7H5NO4

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

In 2019 EUR J MED CHEM published article about SM PROTEINS; PRMT5; METHYLATION; GROWTH; IDENTIFICATION; COMPLEX; PICLN in [Shao, Jingwei; Duan, Wenhu] Chinese Acad Sci, Shanghai Inst Mat Med, Dept Med Chem, Shanghai 201203, Peoples R China; [Zhu, Kongkai; Tao, Hongrui] Univ Jinan, Sch Biol Sci & Technol, Jinan 250022, Shandong, Peoples R China; [Du, Daohai; Zhang, Yuanyuan; Tao, Hongrui; Chen, Zhifeng; Jiang, Hualiang; Chen, Kaixian; Luo, Cheng] Chinese Acad Sci, Shanghai Inst Mat Med, Drug Discovery & Design Ctr, CAS Key Lab Receptor Res,State Key Lab Drug Res, 555 Zuchongzhi Rd, Shanghai 201203, Peoples R China; [Chen, Kaixian; Luo, Cheng] Qingdao Natl Lab Marine Sci & Technol, Open Studio Drugabil Res Marine Nat Prod, Wenhai Rd, Qingdao 266237, Shandong, Peoples R China in 2019, Cited 36. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7. COA of Formula: C7H5NO4

Protein arginine methyltransferases 5 (PRMT5) represents an attractive drug target in epigenetic field for the treatment of leukemia and lymphoma. Here, a series of N-(3-(3,4-dihydroisoquinolin-2(1H)-yl)-2-hydroxypropyl)amide derivatives targeting PRMT5 were designed with structure-based approach and synthesized. Among them, compound 46 showed potent and selective PRMT5 inhibition activity with an IC50 of 8.5 nM, which was approximately equivalent with the phase 1 clinical trial PRMT5 inhibitor GSK-3326595 (IC50 = 5.5 nM). Compound 46 also displayed pronounced anti-proliferative activity in MV4-11 cells (GI(50) =18 nM) and antitumor activity in MV4-11 mouse xenografts model. This molecule can serve as an excellent tool compound for probing the biological function of PRMT5. (C) 2018 Published by Elsevier Masson SAS.

Welcome to talk about 62-23-7, If you have any questions, you can contact Shao, JW; Zhu, KK; Du, DH; Zhang, YY; Tao, HR; Chen, ZF; Jiang, HL; Chen, KX; Luo, C; Duan, WH or send Email.. COA of Formula: C7H5NO4

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

COA of Formula: C7H5NO4. I found the field of Chemistry very interesting. Saw the article Amine decorated polystyrene nanobeads incorporating pi-conjugated OPV chromophore for picric acid sensing in water published in 2020.0, Reprint Addresses Makkad, SK (corresponding author), Govt Autonomous NPG Coll Sci, Raipur, Madhya Pradesh, India.; Makkad, SK (corresponding author), Natl Chem Lab, CSIR, Pune, Maharashtra, India.. The CAS is 62-23-7. Through research, I have a further understanding and discovery of 4-Nitrobenzoic acid.

A solution as well as solid state based sensor has been developed for selective detection of picric acid (PA) in water. Oligo (p-phenylenevinylene) (OPV) incorporated polystyrene nanobeads (PS-OPV-NH2) having an average size of 180 nm have been synthesized through miniemulsion polymerization. Amine (-NH2) functionalization was performed on the nanobead surface to enhance the efficiency of the sensor among a library of other nitro-organics and library of cations and anions.

COA of Formula: C7H5NO4. About 4-Nitrobenzoic acid, If you have any questions, you can contact Makkad, SK or concate me.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Recently I am researching about CATALYTIC ASYMMETRIC-SYNTHESIS; PARA-QUINONE METHIDES; UNSATURATED PYRAZOLONES; SULFUR YLIDES; SPIROPYRAZOLONES; CYCLIZATION; OXINDOLES; SPIROCYCLOPROPANATION; SPIROOXINDOLES; IDENTIFICATION, Saw an article supported by the NSFCNational Natural Science Foundation of China (NSFC) [21572262, 21572138]. Recommanded Product: 4-Nitrobenzoic acid. Published in ROYAL SOC CHEMISTRY in CAMBRIDGE ,Authors: Liu, M; Liu, CF; Zhang, J; Xu, YJ; Dong, L. The CAS is 62-23-7. Through research, I have a further understanding and discovery of 4-Nitrobenzoic acid

A highly efficient cascade annulation approach was developed for the synthesis of novel spiro-cyclopropyl fused pyrazolin-5-ones from pyrazole-3-ketone substrates and two-component sulfur ylides in an acidic environment. This metal-free one-pot reaction has the advantages of easily available active materials, simple operation and brand new spirocyclic skeletons.

Bye, fridends, I hope you can learn more about C7H5NO4, If you have any questions, you can browse other blog as well. See you lster.. Recommanded Product: 4-Nitrobenzoic acid

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Recently I am researching about CATALYZED C-O; ARYL ESTERS; NICKEL; AZOLES; SILYLATION; AMINATION; CLEAVAGE; KETONES; AMIDE, Saw an article supported by the National Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21861030, 21462031]; Program for Young Talents of Science and Technology in Universities of Inner Mongolia Autonomous Region [NJYT-17-A22]; Research Innovation Fund of Inner Mongolia Normal University [CXJJS17090]. Application In Synthesis of 4-Nitrobenzoic acid. Published in ROYAL SOC CHEMISTRY in CAMBRIDGE ,Authors: Ma, HP; Bai, CLM; Bao, YS. The CAS is 62-23-7. Through research, I have a further understanding and discovery of 4-Nitrobenzoic acid

A site-selective supported palladium nanoparticle catalyzed Suzuki-Miyaura cross-coupling reaction with heteroaryl esters and arylboronic acids as coupling partners was developed. This methodology provides a heterogeneous catalytic route for aryl ketone formation via C(acyl)-O bond activation of esters by successful suppression of the undesired decarbonylation phenomenon. The catalyst can be reused and shows high activity after eight cycles. The XPS analysis of the catalyst before and after the reaction suggested that the reaction might be performed via a Pd-0/Pd-II catalytic cycle that began with Pd-0.

Application In Synthesis of 4-Nitrobenzoic acid. About 4-Nitrobenzoic acid, If you have any questions, you can contact Ma, HP; Bai, CLM; Bao, YS or concate me.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

SDS of cas: 62-23-7. In 2019 CHEMISTRYSELECT published article about BIOLOGICAL EVALUATION; DIABETES-MELLITUS; INHIBITORS; ANTIBACTERIAL; PYRIMIDINE; DIET in [Reddy, Bijivemula N.; Pathak, Madhvesh] Vellore Inst Technol, Sch Adv Sci, Vellore 632014, Tamil Nadu, India; [Ruddarraju, Radhakrishnam Raju] Factory Plot 79-B&C, Patancheru 502307, Andhra Pradesh, India; [Ruddarraju, Radhakrishnam Raju] Jawaharlal Nehru Technol Univ, Hyderabad 500085, Telangana, India; [Kiran, Gangarapu] Anurag Grp Inst, Dept Pharmaceut Anal & Chem, Sch Pharm, Ghatkesar M, Telangana, India; [Reddy, Anreddy Rama Narsimha] Jyothishmathi Inst Pharmaceut Sci, Dept Pharmacol, Karimnagar 505481, Telangana, India in 2019, Cited 45. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7.

A new series of Pyrazolo[3,4-d]pyrimidine containing amide derivatives (8 a-l) were designed, synthesized, and evaluated for their in vitro alpha-amylase inhibitory activity. The IC50 values of the target compounds ranged from 1.60 +/- 0.48 to 2.04 +/- 1.20 mu M as compared to the standard acarbose 1.73 +/- 0.05 mu M. All the Pyrazolo[3,4-d]pyrimidine amide derivatives displayed good inhibitory activities, while seven analogs (8 d, 8 f, 8 g, 8 h, 8 i, 8 j and 8 k) exhibited more or less equipotent activity with IC50 values 1.77 +/- 2.84, 1.65 +/- 0.45, 1.66 +/- 2.24, 1.73 +/- 0.37, 1.60 +/- 0.48, 1.75 +/- 0.36 and 1.64 +/- 0.03 mu M respectively. Further, the most potent alpha-amylase inhibitors 8 d and 8 k were also screened for their in vivo antidiabetic activity against alloxan induced diabetic rat model at the dose of 25 and 50 mg/kg. Oral administration of these tested compounds significantly reduced the fasting blood glucose levels in dose dependent manner. The hypoglycemic effects of these compounds were more evident at 3 h and 5 h after administration of tested compounds which was similar to the effect displayed by the positive control. In addition, the binding energies calculated from the docking studies with the alpha-amylase enzyme (PDB ID: 1HNY) and biological activities indicate that the compounds containing nitro moiety on the phenyl group contributed significantly towards the antidiabetic activity.

SDS of cas: 62-23-7. Welcome to talk about 62-23-7, If you have any questions, you can contact Reddy, BN; Ruddarraju, RR; Kiran, G; Pathak, M; Reddy, ARN or send Email.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Recommanded Product: 62-23-7. Shouksmith, AE; Gawel, JM; Nawar, N; Sina, D; Raouf, YS; Bukhari, S; He, LY; Johns, AE; Manaswiyoungkul, P; Olaoye, OO; Cabral, AD; Sedighi, A; de Araujo, ED; Gunning, PT in [Shouksmith, Andrew E.; Gawel, Justyna M.; Nawar, Nabanita; Sina, Diana; Raouf, Yasir S.; Bukhari, Shazreh; He, Liying; Johns, Alexandra E.; Manaswiyoungkul, Pimyupa; Olaoye, Olasunkanmi O.; Cabral, Aaron D.; Sedighi, Abootaleb; de Araujo, Elvin D.; Gunning, Patrick T.] Univ Toronto Mississauga, Dept Chem & Phys Sci, 3359 Mississauga Rd, Mississauga, ON L5L 1C6, Canada published Class I/IIb-Selective HDAC Inhibitor Exhibits Oral Bioavailability and Therapeutic Efficacy in Acute Myeloid Leukemia in 2020.0, Cited 25.0. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7.

The HDAC inhibitor 4-tert-butyl-N-(4-(hydroxycarbamoyl)phenyl)benzamide (AES-350, 51) was identified as a promising preclinical candidate for the treatment of acute myeloid leukemia (AML), an aggressive malignancy with a meagre 24% 5-year survival rate. Through screening of low-molecular-weight analogues derived from the previously discovered novel HDAC inhibitor, AES-135, compound 51 demonstrated greater HDAC isoform selectivity, higher cytotoxicity in MV4-11 cells, an improved therapeutic window, and more efficient absorption through cellular and lipid membranes. Compound 51 also demonstrated improved oral bioavailability compared to SAHA in mouse models. A broad spectrum of experiments, including FACS, ELISA, and Western blotting, were performed to support our hypothesis that 51 dose-dependently triggers apoptosis in AML cells through HDAC inhibition.

Recommanded Product: 62-23-7. Bye, fridends, I hope you can learn more about C7H5NO4, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Quality Control of 4-Nitrobenzoic acid. I found the field of Pharmacology & Pharmacy very interesting. Saw the article Battle tactics against MMP-9; discovery of novel non-hydroxamate MMP-9 inhibitors endowed with PI3K/AKT signaling attenuation and caspase 3/7 activation via Ugi bis-amide synthesis published in 2020.0, Reprint Addresses Ayoup, MS (corresponding author), Alexandria Univ, Fac Sci, Chem Dept, Alexandria 21321, Egypt.. The CAS is 62-23-7. Through research, I have a further understanding and discovery of 4-Nitrobenzoic acid.

Matrix metalloproteinases (MMPs) are major modulators of the tumor microenvironment. They participate in extracellular matrix turnover, tumor growth, angiogenesis and metastasis. Accordingly, MMPs inhibition seems to be ideal solution to control cancer. Many MMPs inhibitors have been introduced ranging from hydroxamate-based peptidomimetics to the next generation non-hydroxamate inhibitors. Among MMPs, MMP-9 is attractive druggable anticancer target. Studies showed that inhibiting AKT, the central signaling node of MMP-9 upregulation, provides additional MMP-9 blockade. Furthermore, caspase-dependent AKT cleavage leads to cell death. Herein, Ugi MCR was utilized as a rapid combinatorial approach to generate various decorated bis-amide scaffolds as dual MMP-9/AKT inhibitors endowed with caspase 3/7 activation potential. The target adducts were designed to mimic the thematic structural features of non-hydroxamate MMP inhibitors. p-Nitrophenyl isonitrile 1 was utilized as structure entry to Ugi products with some structural similarities to amide-based caspase 3/7 activators. Besides, various acids, amines and aldehydes were employed as Ugi educts to enrich the SAR data. All adducts were screened for cytotoxicity against normal fibroblasts and three cancer cell lines; MCF-7, NFS-60 and HepG-2 utilizing MTT assay. 8,11 and 28 were more active and safer than doxorubicin with single-digit nM IC50 and promising selectivity. Mechanistically, they exhibited dual MMP-9/AKT inhibition at single-digit nM IC50 with excellent selectivity over MMP-1,-2 and -13, and induced >51% caspase 3/7 activation. Consequently, they induced >49% apoptosis as detected by flow cytometric analysis, and inhibited cell migration (metastasis) up to 97% in cancer cells. Docking simulations were nearly consistent with enzymatic evaluation, also declared possible binding modes and essential structure features of active compounds. In silico physicochemical properties, ligand efficiency and drug-likeness metrics were reasonable for all adducts. Interestingly, 8 and 28 can be considered as drug-like candidates. (C) 2019 Elsevier Masson SAS. All rights reserved.

Quality Control of 4-Nitrobenzoic acid. About 4-Nitrobenzoic acid, If you have any questions, you can contact Ayoup, MS; Fouad, MA; Abdel-Hamid, H; Ramadan, E; Abu-Serie, MM; Noby, A; Teleb, M or concate me.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Recently I am researching about DISCOVERY; EFFICIENT, Saw an article supported by the . Published in PERGAMON-ELSEVIER SCIENCE LTD in OXFORD ,Authors: Chen, L; Luo, GL. The CAS is 62-23-7. Through research, I have a further understanding and discovery of 4-Nitrobenzoic acid. SDS of cas: 62-23-7

A fast and convenient method using the Mukaiyama reagent was developed to prepare acyl sulfonamides from carboxylic acids and sulfonamides. This methodology is effective for a range of acids and sulfonamides proceeding in moderate to good yields with the majority of reactions complete within one hour under the optimized condition. (C) 2018 Elsevier Ltd. All rights reserved.

Welcome to talk about 62-23-7, If you have any questions, you can contact Chen, L; Luo, GL or send Email.. SDS of cas: 62-23-7

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Recommanded Product: 4-Nitrobenzoic acid. In 2020 RSC ADV published article about SELECTIVE HYDROGENATION; EFFICIENT PHOTOCATALYST; NITROBENZENE REDUCTION; CARBON NANOTUBES; ACTIVE-SITES; SURFACE; NITROAROMATICS; ACTIVATION; PARTICLES; MECHANISM in [Han, Wenpeng; Li, Xuekuan; Ma, Ben; Du, Mingxian; Zhou, Ligong; Yang, Ying; Zhang, Ye; Ge, Hui] Chinese Acad Sci, Inst Coal Chem, Taiyuan 030001, Peoples R China; [Han, Wenpeng] Univ Chinese Acad Sci, Beijing 100049, Peoples R China; [Wang, Shanmin] Southern Univ Sci & Technol, Dept Phys, Shenzhen 518055, Guangdong, Peoples R China in 2020, Cited 56. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7.

The effect of Fe, Co and Ni promoters on supported MoS2 catalysts for hydrogenation of nitroarenes were systematically investigated via experiment, characterization and DFT calculation. It was found that the addition of promoters remarkably improved the reaction activity in a sequence of Ni > Co > Fe > Mo. Meanwhile Ni promoted catalyst with the best performance showed good recyclability and chemoselectivity for a wide substrate scope. The characterization results revealed that the addition of promoters decreased the interaction between Mo and support and facilitated the reductive sulfidation of Mo species to produce more coordinated unsaturated sites (CUS). DFT calculations showed that the addition of promoters increased the formation of CUS, and enhanced the adsorption of hydrogen. The influence degree of promoters followed the sequence Ni > Co > Fe > Mo, which was consistent with those of the activities. Nitrobenzene hydrogenation and hydrogen activation occurred at the S and Mo edge, respectively. The adsorbed hydrogen diffused from the Mo edge to the S edge to participate in the hydrogenation reaction. Mechanism investigation showed that the main reason for increased activity by the addition of promoters was the increase of amounts of CUS and the secondary reason was the augmentation of intrinsic activity of CUS. The present studies give a new understanding for promoter modified MoS2 catalysts applied for hydrogenation of nitroarenes.

Welcome to talk about 62-23-7, If you have any questions, you can contact Han, WP; Wang, SM; Li, XK; Ma, B; Du, MX; Zhou, LG; Yang, Y; Zhang, Y; Ge, H or send Email.. Recommanded Product: 4-Nitrobenzoic acid

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem