Novel phenotypic outcomes identified for a public collection of approved drugs from a publicly accessible panel of assays was written by Lee, Jonathan A.;Shinn, Paul;Jaken, Susan;Oliver, Sarah;Willard, Francis S.;Heidler, Steven;Peery, Robert B.;Oler, Jennifer;Chu, Shaoyou;Southall, Noel;Dexheimer, Thomas S.;Smallwood, Jeffrey;Huang, Ruili;Guha, Rajarshi;Jadhav, Ajit;Cox, Karen;Austin, Christopher P.;Simeonov, Anton;Sittampalam, G. Sitta;Husain, Saba;Franklin, Natalie;Wild, David J.;Yang, Jeremy J.;Sutherland, Jeffrey J.;Thomas, Craig J.. And the article was included in PLoS One in 2015.Formula: C20H15ClN4 This article mentions the following:
Phenotypic assays have a proven track record for generating leads that become first-in-class therapies. Whole cell assays that inform on a phenotype or mechanism also possess great potential in drug repositioning studies by illuminating new activities for the existing pharmacopeia. The National Center for Advancing Translational Sciences (NCATS) pharmaceutical collection (NPC) is the largest reported collection of approved small mol. therapeutics that is available for screening in a high-throughput setting. Via a wide-ranging collaborative effort, this library was analyzed in the Open Innovation Drug Discovery (OIDD) phenotypic assay modules publicly offered by Lilly. The results of these tests are publically available online at www.ncats.nih.gov/expertise/preclin./pd2 and via the PubChem Database (AID 1117321). Phenotypic outcomes for numerous drugs were confirmed, including sulfonylureas as insulin secretagogues and the anti-angiogenesis actions of multikinase inhibitors sorafenib, axitinib and pazopanib. Several novel outcomes were also noted including the Wnt potentiating activities of rotenone and the antifolate class of drugs, and the anti-angiogenic activity of cetaben. In the experiment, the researchers used many compounds, for example, N-(4-Chlorophenyl)-4-(pyridin-4-ylmethyl)phthalazin-1-amine (cas: 212141-54-3Formula: C20H15ClN4).
N-(4-Chlorophenyl)-4-(pyridin-4-ylmethyl)phthalazin-1-amine (cas: 212141-54-3) belongs to phthalazine derivatives. Phthalazines, as an important class of bicyclic N-heterocycles, have attracted sizable attention due to their valuable biological and pharmacological activities. In addition, phthalazines are known as serotonin reuptake inhibitors and are considered as anti-depression agents.Formula: C20H15ClN4
Referemce:
Phthalazine – Wikipedia,
Phthalazine | C8H6N2 – PubChem