Hydrazinolysis study of phthalimido- and phthalisoimido-penicillin amide derivatives was written by Ceric, Helena;Sindler-Kulyk, Marija. And the article was included in ARKIVOC (Gainesville, FL, United States) in 2009.Electric Literature of C9H8N2O2 This article mentions the following:
New phthalimido-penicillin amide (6-PhtPABn, I) and phthalisoimido-penicillin amide (6-isoPhtPABn, II) were prepared and the susceptibility of their different carbonyl functions toward hydrazine derivatives investigated in order to establish the feasibility of dephthaloylation within penicillin class compounds Hydrazinolysis of I resulted in dephthaloylation and β-lactam ring opening into thiazolidine derivatives, while in the case of II, the desired amino-penicillin amide was isolated in low yield. In the experiment, the researchers used many compounds, for example, 2-Methyl-2,3-dihydrophthalazine-1,4-dione (cas: 18393-54-9Electric Literature of C9H8N2O2).
2-Methyl-2,3-dihydrophthalazine-1,4-dione (cas: 18393-54-9) belongs to phthalazine derivatives. Pyridazine and phthalazine have quite different spectroscopic properties compared with their isomers, pyrazine and quinoxaline. Phthalazine derivatives are also considered as p38MAP kinase inhibitors, selective binders of gamma-aminobutyric acid (GABA) receptors, cyclooxygenase-2 (COX-2) inhibitors, and high-affinity ligands of voltages gated calcium channels.Electric Literature of C9H8N2O2
Referemce:
Phthalazine – Wikipedia,
Phthalazine | C8H6N2 – PubChem