Design, synthesis and antitumor activity of phthalazine-1,4-dione-based menaquinone analogs was written by Fujii, Shinya;Miura, Takahiro;Oikawa, Tsuyoshi;Qin, Xian-Yang;Kojima, Soichi;Kagechika, Hiroyuki. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2021.Related Products of 18393-54-9 This article mentions the following:
New chemotherapeutics are needed to treat hepatocellular carcinoma (HCC), and menaquinones, homologs of vitamin K consisting of a 1,4-naphthoquinone core and a (poly)isoprene chain, are potential candidates. In this study, we designed and synthesized a series of phthalazine-1,4-dione-based menaquinone analogs such as I. Among them, compounds bearing the intact isoprene chain exhibited selective antiproliferative activity towards HCC cell line JHH7, as compared with normal hepatocytes. The geranyl derivative I showed submicromolar potency, and might be a promising lead compound for anticancer agents. In the experiment, the researchers used many compounds, for example, 2-Methyl-2,3-dihydrophthalazine-1,4-dione (cas: 18393-54-9Related Products of 18393-54-9).
2-Methyl-2,3-dihydrophthalazine-1,4-dione (cas: 18393-54-9) belongs to phthalazine derivatives. Like many other isomeric benzodiazines, phthalazine derivatives reveal numerous pharmacological and biological activities such as anticonvulsant, antitumor, antiproliferative, antiepileptic, anti-inflammatory, and vasorelaxant. Both pyridazine and phthalazine give rise to very good TREPR signals in rigid media at low temperatures.Related Products of 18393-54-9
Referemce:
Phthalazine – Wikipedia,
Phthalazine | C8H6N2 – PubChem