Analyzing the synthesis route of 152265-57-1

With the synthetic route has been constantly updated, we look forward to future research findings about 7-Bromophthalazin-1(2H)-one,belong phthalazine compound

As a common heterocyclic compound, it belong phthalazine compound,7-Bromophthalazin-1(2H)-one,152265-57-1,Molecular formula: C8H5BrN2O,mainly used in chemical industry, its synthesis route is as follows.,152265-57-1

A mixture of compound 50-d (600mg, 2.67mmol) and POCl3 (8mL) was heated to reflux for 1.5h, cooled toroom temperature and concentrated under reduced pressure. The residue was dissolved in DCM (40mL), washed inturn with saturated sodium bicarbonate (40mL) and saturated brine (10mL), dried over anhydrous sodium sulfate, filteredand concentrated under reduced pressure. The residue was purified by silica column chromatography (PE:EA = 3:1) togive compound 50-c (500mg, yield 75%). LC-MS (ESI): m/z = 243 [M+H]+.

With the synthetic route has been constantly updated, we look forward to future research findings about 7-Bromophthalazin-1(2H)-one,belong phthalazine compound

Reference£º
Patent; Shanghai Yingli Pharmaceutical Co. Ltd.; XU, Zusheng; ZHANG, Nong; SUN, Qingrui; WU, Tianzhi; (104 pag.)EP3275867; (2018); A1;,
Phthalazine – Wikipedia
Phthalazine | C8H6N2 – PubChem