In homogeneous catalysis, the catalyst is in the same phase as the reactant. The number of collisions between reactants and catalyst is at a maximum.In a patent, 253-52-1, name is Phthalazine, introducing its new discovery. Recommanded Product: Phthalazine
Synthesis and reactions of some novel 4-biphenyl-4-(2H)-phthalazin-1-one derivatives with an expected antimicrobial activity
In this study reaction of 1-(biphenyl-4-carbonyl)benzoic acid ( 1) with hydrazine hydrate, phenyl hydrazine, acetyl hydrazine and benzoyl hydrazine in boiling dry benzene gave the corresponding 4-biphenyl-4-yl-( 2H)-phthalazin-1-one ( 2a-d), respectively. The structure of 2c was established via its reaction with 2-chlorobenzaldehyde, 2-nitrobenzaldehyde in ethanol to give the chalcones 3a,b, respectively. On the other hand, the cyclocondensation of the acid 1 with semicarbazide and thiosemicarbazide in sodium acetate gave phthalazinone amide/thioamide 4a,b, respectively. The reaction of 1 with hydroxyl amine hydrochloride in different media was also studied, to give the oxime derivative 5, which was readily converted to benzooxazin-1-one derivative 6 by boiling in acetic anhydride. Compound 6 was also obtained, when the acid 1 was reacted with hydroxyl amine hydrochloride in boiling pyridine. In addition, the phthalazinone derivative 2a reacted under Mannich reaction condition with phthalimide, morpholine, o-crezole and beta-naphthol to give Mannich bases 7a-d, respectively. The structural assignment of the new compounds was based on analytical and spectral data. And some of the new products showed antimicrobial activity.
We¡¯ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, the role of 253-52-1, and how the biochemistry of the body works.Recommanded Product: Phthalazine
Reference£º
Phthalazine – Wikipedia,
Phthalazine | C8H6N17 – PubChem