In heterogeneous catalysis, the catalyst is in a different phase from the reactants. SDS of cas: 72702-95-5, At least one of the reactants interacts with the solid surface in a physical process called adsorption in such a way. 72702-95-5, name is 2-(3-(4-Bromo-2-fluorobenzyl)-4-oxo-3,4-dihydrophthalazin-1-yl)acetic acid. In an article£¬Which mentioned a new discovery about 72702-95-5
Aldose reductase as a drug target for treatment of diabetic nephropathy: Promises and challenges
Diabetic nephropathy (DN) is one of the most serious microvascular complications of diabetes mellitus and the leading cause of end stage renal disease. One of the key pathways activated in DN is the polyol pathway, in which glucose is converted to sorbitol (a relatively nonmetabolizable sugar) by the enzyme aldose reductase (AR). Shunting of glucose into this pathway causes disruption to glucose metabolism and subsequently damages the tissues via increased oxidative stress, protein kinase c activation and production of advanced glycation end products (AGE) in the kidney. This review aims to provide a comprehensive overview of the AR enzyme structure, substrate specificity and topology in normal physiology; to elaborate on the deleterious effects of AR activation in DN; and to summarize the potential therapeutic benefits and major challenges associated with AR inhibition in patients with DN.
I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 72702-95-5, help many people in the next few years.SDS of cas: 72702-95-5
Reference£º
Phthalazine – Wikipedia,
Phthalazine | C8H6N863 – PubChem