Synthetic Route of 19064-73-4, Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics.In a document type is Article, and a compound is mentioned, 19064-73-4, 4-Bromophthalazin-1(2H)-one, introducing its new discovery.
Development of novel proteasome inhibitors based on phthalazinone scaffold
In this study we designed a series of proteasome inhibitors using pyridazinone as initial scaffold, and extended the structure with rational design by computer aided drug design (CADD). Two different synthetic routes were explored and the biological evaluation of the phthalazinone derivatives was investigated. Most importantly, electron positive triphenylphosphine group was first introduced in the structure of proteasome inhibitors and potent inhibition was achieved. As 6c was the most potent inhibitor of proteasome, we examined the structure-activity relationship (SAR) of 6c analogs.
Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Synthetic Route of 19064-73-4. In my other articles, you can also check out more blogs about 19064-73-4
Reference£º
Phthalazine – Wikipedia,
Phthalazine | C8H6N702 – PubChem