One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, Application In Synthesis of Phthalazine, such as the rate of change in the concentration of reactants or products with time.In a article, mentioned the application of 253-52-1, Name is Phthalazine, molecular formula is C8H6N2
2H-Indazolo[2,1-b]phthalazine-trione derivatives: Inhibition on some metabolic enzymes and molecular docking studies
In this study, substituted 2H-indazolo[2,1-b]phthalazine-1,6,11-trione compounds (4a?d) obtained via one-pot three-component condensation reaction of aromatic aldehydes, cyclic 1,3-dione, and phthalhydrazide in ethanol catalyzed by Y(OTf)3 showed satisfactory inhibitory effects against some important enzymes. Also, these molecules had Ki values in the row of 185.92 ¡À 36.03-294.82 ¡À 50.76 nM vs carbonic anhydrase I (CA I), 204.93 ¡À 46.90-374.10 ¡À 83.63 nM against human CA II, 937.16 ¡À 205.82-1021.83 ¡À 193.66 nM against alpha-glycosidase (alpha-Gly), respectively. For cholinesterase enzymes, the Ki values were found in the range of 47.26 ¡À 9.62-72.05 ¡À 19.47 nM against acetylcholinesterase (AChE) and 65.03 ¡À 9.88-102.83 ¡À 25.04 nM against butyrylcholinesterase (BChE), respectively. The inhibition effects of these compounds against enzymes whose name are AChE, BChE, alpha-Gly, hCA I, and hCA II, were compared with control molecules like tacrine, acarbose, and acetazolamide.
One of the oldest and most widely used commercial enzyme inhibitors is aspirin, Application In Synthesis of Phthalazine, which selectively inhibits one of the enzymes involved in the synthesis of molecules that trigger inflammation. you can also check out more blogs about 253-52-1
Reference£º
Phthalazine – Wikipedia,
Phthalazine | C8H6N437 – PubChem