Some tips on 1,4-Dioxo-1,2,3,4-tetrahydrophthalazine-6-carboxylic acid

As a common heterocyclic compound, it belongs to phthalazine compound, name is 1,4-Dioxo-1,2,3,4-tetrahydrophthalazine-6-carboxylic acid, and cas is 42972-13-4, its synthesis route is as follows.,42972-13-4

l-Bromo-4-oxo-3,4-dihydro-phthalazine-6-carboxylic acidl,4-Dioxo-l,2,3,4-tetrahydro-phthalazine-6-carboxylic acid (91.Og, 0.44mol) was suspended in dichloroethane (1.0L) and phosphorus pentabromide (761.Og,1.77mol) was added in three portions and the reaction heated to reflux for 24 hours. The reaction was cooled to room temperature and poured onto ice (2.50kg) EPO and the resulting precipitate filtered and washed with water to give the crude product (13Og).This crude material was suspended in acetic acid (1.60L) and heated to 125C for 2 hours. The reaction was cooled to room temperature and poured onto ice (1.5kg) and the resulting precipitate filtered. The solid was washed with water and dried to give the title compound (85g, 73% yield) as a yellow solid. MS (ESI+) = (M+H)+ 310 & 312

With the complex challenges of chemical substances, we look forward to future research findings about 42972-13-4,belong phthalazine compound

Reference£º
Patent; F. HOFFMANN-LA ROCHE AG; WO2006/32518; (2006); A1;,
Phthalazine – Wikipedia
Phthalazine | C8H6N2 – PubChem