Application of 253-52-1, Catalysts function by providing an alternate reaction mechanism that has a lower activation energy than would be found in the absence of the catalyst. In some cases, the catalyzed mechanism may include additional steps.In a article, 253-52-1, molcular formula is C8H6N2, introducing its new discovery.
An alpha5 gabaa receptor inverse agonist, alpha5ia, attenuates amyloid beta-induced neuronal death in mouse hippocampal cultures
Alzheimer?s disease (AD) is a progressive neurodegenerative disorder for which no cognition-restoring therapies exist. Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the brain. Increasing evidence suggests a remodeling of the GABAergic system in AD, which might represent an important therapeutic target. An inverse agonist of alpha5 subunit-containing GABAA receptors (alpha5GABAARs), 3-(5-Methylisoxazol-3-yl)-6-[(1-methyl-1,2,3-triazol-4-yl)methyloxy]-1,2,4-triazolo[3?a]phthalazine (alpha5IA) has cognition-enhancing properties. This study aimed to characterize the effects of alpha5IA on amyloid beta (Abeta1?42)-induced molecular and cellular changes. Mouse primary hippocampal cultures were exposed to either Abeta1-42 alone, or alpha5IA alone, alpha5IA with Abeta1?42 or vehicle alone, and changes in cell viability and mRNA expression of several GABAergic signaling components were assessed. Treatment with 100 nM of alpha5IA reduced Abeta1?42-induced cell loss by 23.8% (p < 0.0001) after 6 h and by 17.3% after 5 days of treatment (p < 0.0001). Furthermore, we observed an Abeta1-42-induced increase in ambient GABA levels, as well as upregulated mRNA expression of the GABAAR alpha2,alpha5,beta2/3 subunits and the GABABR R1 and R2 subunits. Such changes in GABARs expression could potentially disrupt inhibitory neurotransmission and normal network activity. Treatment with alpha5IA restored Abeta1-42-induced changes in the expression of alpha5GABAARs. In summary, this compound might hold neuroprotective potential and represent a new therapeutic avenue for AD. The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 253-52-1 is helpful to your research. Application of 253-52-1
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Phthalazine – Wikipedia,
Phthalazine | C8H6N459 – PubChem