Archives for Chemistry Experiments of 4-Bromophthalazin-1(2H)-one

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions.SDS of cas: 19064-73-4, you can also check out more blogs about19064-73-4

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Phthalazinone pyrazoles as potent, selective, and orally bioavailable inhibitors of Aurora-A kinase

The inhibition of Aurora kinases in order to arrest mitosis and subsequently inhibit tumor growth via apoptosis of proliferating cells has generated significant discussion within the literature. We report a novel class of Aurora kinase inhibitors based upon a phthalazinone pyrazole scaffold. The development of the phthalazinone template resulted in a potent Aurora-A selective series of compounds (typically >1000-fold selectivity over Aurora-B) that display good pharmacological profiles with significantly improved oral bioavailability compared to the well studied Aurora inhibitor VX-680.

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions.SDS of cas: 19064-73-4, you can also check out more blogs about19064-73-4

Reference£º
Phthalazine – Wikipedia,
Phthalazine | C8H6N700 – PubChem