Related Products of 763114-26-7, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.763114-26-7, Name is 2-Fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)methyl)benzoic acid, molecular formula is C16H11FN2O3. In a Patent£¬once mentioned of 763114-26-7
A phthalazinone derivative and its preparation method and medical use (by machine translation)
The present invention provides a phthalazinone derivative and its preparation method and medical use. In order to O-aldehyde benzoic acid as the raw material, by reaction with methyl (3 – oxo – 1, 3 – ISO-benzofuran – 1 – yl) phosphonic acid dimethyl ester, the compound with 3 – cyano – 4 – fluorophenyl with formaldehyde in the presence of triethylamine to produce (Z, E) – 2 – fluoro – 5 – [(3 – oxoisoindoline benzofuran – 1 (3 H) – ylidene) methyl] benzonitrile, it is hydrazine hydrate is reduced to 2 – fluoro – 5 – [(4 – oxo – 3, 4 – […] – 1 – yl) methyl] benzoic acid; benzene formaldehyde or substituted aryl formaldehyde or furfural as raw materials, with malonic acid in the Knoevenagel reaction, the obtained acrylic acid or substituted the acrylic acid or furan – 2 – acrylic acid, with 1 – tert-butoxycarbonyl piperazine generating amide reaction, the product in the presence of trifluoroacetic acid takes off uncle butoxycarbonyl, the obtained product with 2 – fluoro – 5 – [(4 – oxo – 3, 4 – […] – 1 – yl) methyl] benzoic acid generating amide reaction, to obtain a series of (E)- 4 – {3 – [4 – [(3 – substituted aromatic) acryloyl] piperazine – 1 – carbonyl] – 4 – fluorobenzyl} – 2 H – phthalazine – 1 – one derivatives. The initial pharmacological activity screening results show, the invention of the general formula of the compounds have certain in vitro PARP – 1 inhibition ability and the in vitro anti-tumor cell proliferation activity. The said compound of general structure is as follows: In the above formula: Ar selected from or R1 , R2 , R3 , R3 , R4 , R5 Can be a hydrogen atom, a fluorine atom, chlorine atom, bromine atom, methyl, methoxy, trifluoromethyl, nitro. (by machine translation)
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Reference£º
Phthalazine – Wikipedia,
Phthalazine | C8H6N754 – PubChem