One of the major reasons is to use measurements of the macroscopic properties of a system, 119-39-1, such as the rate of change in the concentration of reactants or products with time, to discover the sequence of events that occur at the molecular level.Phthalazin-1(2H)-one, cas is 119-39-1,the phthalazine compound, introduce a new downstream synthesis route.
Weighing 2H-phthalazin-1-one (150 mmol), tert-butyl 5-{[(2-chlorophenoxy)carbonyl]amino}-3,4-dihydroisoquinoline-2(1H)-carboxylate (195 mmol) in reaction bottle, adding DMF100ml, 55 C lower reaction overnight, stopping the reaction, by adding water 100 ml, dichloromethane 200 ml, extraction, separation of the organic phase, the aqueous phase to continue to dichloromethane is used for extraction (3 * 50 ml), the combined organic phase, anhydrous sodium sulfate drying, column chromatography purification obtained title compound.
The chemical industry reduces the impact on the environment during synthesis,119-39-1,Phthalazin-1(2H)-one,I believe this compound will play a more active role in future production and life.
Reference£º
Patent; Nanjing Advanced Biological Materials And Process Equipment Institute Co., Ltd.; Guo Chengjie; (12 pag.)CN109481442; (2019); A;,
Phthalazine – Wikipedia
Phthalazine | C8H6N2 – PubChem