One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, such as the rate of change in the concentration of reactants or products with time. 622-88-8, Name is (4-Bromophenyl)hydrazine hydrochloride, formurla is C6H8BrClN2. In a document, author is Malinowski, Zbigniew, introducing its new discovery. Recommanded Product: (4-Bromophenyl)hydrazine hydrochloride.
Synthesis of 4-alkylsulfanylphthalazin-1(2H)-ones via palladium catalyzed sulfanylation of substituted 4-bromophthalazin-1 (2H)-ones
The synthesis of a series of new alkylsulfanyl phthalazinone and phthalazine derivatives is described. The target compounds were efficiently synthesized in a four step sequence, consisting of (1) cyclization of 2-formylbenzoic acid with hydrazine hydrate to form phthalazinone, (2) the direct bromination of phthalazinone core with KBr3, (3) alkylation of the obtained 4-bromolactam (Mitsunobu procedure) to make N- and also O-alkyl derivatives and finally (4) palladium-catalyzed coupling reactions of 2-alkyl-4bromophthalazinone and 1-allcyloxy-4-bromophthalazine derivatives with aliphatic mercaptanes. Furthermore, the synthesis of 2-methyl-8-(propan-2-yl)sulfanyl-pyrido[3,44pyridazin-1(2H)-one from 2methyl-pyrido[3,4-d]pyridazin-1(2H)-one via bromination reaction with KBr3 and subsequent sulfanylation by isopropyl mercaptan under catalyzed coupling reaction conditions is also described. (C) 2016 Elsevier Ltd. All rights reserved.
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Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem