Application of 35661-39-3, As an important bridge between the micro and macro material world, chemistry is one of the main methods and means for humans to understand and transform the material world. 35661-39-3, Name is Fmoc-Ala-OH, SMILES is C[C@H](NC(OCC1C2=C(C3=C1C=CC=C3)C=CC=C2)=O)C(O)=O, belongs to phthalazines compound. In a article, author is Ma, Long-Xu, introduce new discover of the category.
Synthesis and positive inotropic evaluation of [1,2,4]triazolo [3,4-a]phthalazine and tetrazolo[5,1-a]phthalazine derivatives bearing substituted piperazine moieties
Four series of [1,2,4]triazolo[3,4-a]phthalazine and tetrazolo[5,1-a]phthalazine derivatives bearing substituted piperazine moieties were synthesized and evaluated for their positive inotropic activity by measuring the left atrium stroke volume in isolated rabbit-heart preparations. Several compounds were developed and showed favorable activities compared to the standard drug milrinone, with (4-([1,2,4]triazolo[3,4-a]phthalazin-6-yl) piperazin-1-yl)(p-tolyl) methanone (5g) being identified as the most potent with an increased stroke volume of 19.15 +/- 0.22% (milrinone: 2.46 +/- 0.07%) at a concentration of 3 x 10(-5) M. A preliminary study of mechanism of action revealed that 5g displayed its positive inotropic effect may be related to the PDE-cAMP-PKA signaling pathway. Compounds exhibiting inotropic effects were also evaluated in terms of the chronotropic effects. (c) 2014 Elsevier Ltd. All rights reserved.
Application of 35661-39-3, One of the oldest and most widely used commercial enzyme inhibitors is aspirin, which selectively inhibits one of the enzymes involved in the synthesis of molecules that trigger inflammation. you can also check out more blogs about 35661-39-3.
Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem