The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature. 7524-50-7, Name is H-Phe-OMe.HCl, SMILES is N[C@@H](CC1=CC=CC=C1)C(OC)=O.[H]Cl, in an article , author is Wang Chaojie, once mentioned of 7524-50-7, Quality Control of H-Phe-OMe.HCl.
Synthesis and Antitumor Activity Evaluation of 3,6-Substituted-1,2,4-triazolo[3,4-a]phthalazine Derivatives
With the aim of obtaining potential antitumor candidates with more efficiency and more economic value. A series of 3,6-substituted-1,2,4-triazolo[3,4-a]phthalazine derivatives were synthesized. The target products were obtained via cyclization, chlorination, substitution, cyclization, substituted with phthalic anhydride used as the starting material. The structures of target products are confirmed by H-1 NMR, C-13 NMR, HRMS. A series of 3,6-substituted-1,2,4-triazolo[3,4-a] phthalazine derivatives was evaluated for anticancer activity on four human cancer cell lines including EC-9706, HeLa and MCF-7 by MTT assay. Among them, compound 5d was more cytotoxic against EC-9706 and HeLa cell lines, with IC50 values ranging from 3.9 to 4.5 mu mol.L-1, which are superior or comparable to 5-Fuorouracil. Flow cytometry analysis indicated that compound 5d induced the cellular early apoptosis and cell cycle arrest in G2/M phase in EC-9706.
Interested yet? Read on for other articles about 7524-50-7, you can contact me at any time and look forward to more communication. Quality Control of H-Phe-OMe.HCl.
Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem