Chemistry can be defined as the study of matter and the changes it undergoes. You¡¯ll sometimes hear it called the central science because it is the connection between physics and all the other sciences, starting with biology. 737-31-5, Name is Sodium 3,5-diacetamido-2,4,6-triiodobenzoate, molecular formula is , belongs to phthalazines compound. In a document, author is Ji, Dezhong, Computed Properties of C11H8I3N2NaO4.
Design, synthesis and biological evaluation of anthranilamide derivatives as potent SMO inhibitors
A series of anthranilamide derivatives were designed and synthesized as novel smoothened (SMO) inhibitors based on the SMO inhibitor taladegib (LY2940680), which can also inhibit the SMO-D473H mutant, via a ring-opening strategy. The phthalazine core in LY2940680 was replaced with anthranilamide, which retained the inhibitory activity towards the hedgehog (Hh) signaling pathway as evidenced by a dual luciferase reporter gene assay. Compound 12a displayed the best inhibitory activity against the Hh signaling pathway with IC50 value of 34.09 nM, and exhibited better proliferation inhibitory activity towards the Daoy cell line (IC50=0.48 mu M) than LY2940680 (IC50=0.79 mu M).
Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 737-31-5, in my other articles. Computed Properties of C11H8I3N2NaO4.
Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem