Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics, 81-48-1, Name is 1-Hydroxy-4-(p-tolylamino)anthracene-9,10-dione, SMILES is O=C(C1=C2C=CC=C1)C3=C(NC4=CC=C(C)C=C4)C=CC(O)=C3C2=O, belongs to phthalazines compound. In a document, author is Xin Jingchao, introduce the new discover, Name: 1-Hydroxy-4-(p-tolylamino)anthracene-9,10-dione.
Synthesis and Antitumor Activity of 1-Phenyl-4-substituted Phthalazine Derivatives
In order to find more efficient and economical antitumor drugs, a series of 1-phenyl-4-substituted phthalazine derivatives were synthesized and evaluated for antiproliferative activity in vivo. The structures of the synthesized compounds were confirmed by H-1 NMR, C-13 NMR and HRMS. The antitumor activity of the target compounds was performed against four cancer cell lines by 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2-H-tetrazolium bromide (MTT). The results showed that some compounds had a good antitumor activity, especially, N-(4-methoxyphenyl)-2-((4-phenylphthalazin-1-yl)thio)acetamide (5f) and N-(3-chloro-4-fluorophenyl)-2-(4-(4-phenylphthalazin-1-yl)piperazin-1-yl)acetamide (8c), exhibited better antitumor activities with IC50 values of 8.13 and 9.31 mu mol.L-1 against the human esophageal cancer cells, which were superior to 5-fuorouracil.
The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 81-48-1 is helpful to your research. Name: 1-Hydroxy-4-(p-tolylamino)anthracene-9,10-dione.
Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem