Reactions catalyzed within inorganic and organic materials and at electrochemical interfaces commonly occur at high coverage and in condensed media, causing turnover rates to depend strongly on interfacial structure and composition, 523-27-3, Name is 9,10-Dibromoanthracene, SMILES is BrC1=C2C=CC=CC2=C(Br)C3=CC=CC=C13, in an article , author is Elmeligie, Salwa, once mentioned of 523-27-3, Quality Control of 9,10-Dibromoanthracene.
Design and synthesis of phthalazine-based compounds as potent anticancer agents with potential antiangiogenic activity via VEGFR-2 inhibition
In the designed compounds, either a biarylamide or biarylurea moiety or an N-substituted piperazine motif was linked to position 1 of the phthalazine core. The anti-proliferative activity of the synthesised compounds revealed that eight compounds (6b, 6e, 7b, 13a, 13c, 16a, 16d and 17a) exhibited excellent broad spectrum cytotoxic activity in NCI 5-log dose assays against the full 60 cell panel with GI(50) values ranging from 0.15 to 8.41 mu M. Moreover, the enzymatic assessment of the synthesised compounds against VEGFR-2 tyrosine kinase showed the significant inhibitory activities of the biarylureas (12b, 12c and 13c) with IC(50)s of 4.4, 2.7 and 2.5 mu M, respectively, and with 79.83, 72.58 and 71.6% inhibition of HUVEC at 10 mu M, respectively. Additionally, compounds (7b, 13c and 16a) were found to induce cell cycle arrest at S phase boundary. Compound 7b triggered a concurrent increase in cleaved caspase-3 expression level, indicating the apoptotic-induced cell death.
But sometimes, even after several years of basic chemistry education, it is not easy to form a clear picture on how they govern reactivity! 523-27-3, you can contact me at any time and look forward to more communication. Quality Control of 9,10-Dibromoanthracene.
Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem