Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics, Product Details of 2935-35-5, 2935-35-5, Name is H-Phg-OH, SMILES is O=C(O)[C@@H](N)C1=CC=CC=C1, belongs to phthalazine compound. In a document, author is Li Jiali, introduce the new discover.
Synthesis and Anticonvulsant Activity Evaluation of 6-Substituted-pyrido[3,2-e][1,2,4]triazolo[4,3-a]pyrazine Derivatives
In this paper, a series of 6-substituted-pyrido[3,2-e][1,2,4] triazolo[4,3-a] pyrazine derivatives have been synthesized. Their anticonvulsant activity and neurotoxicity in mice were evaluated by maximal electroshock (MES) and rotarod test, respectively. The structures were confirmed by H-1 NMR, C-13 NMR, MS and HRMS. The experimental results show that 6-phenoxypyrido[3,2-e][1,2,4] triazolo[4,3-a]pyrazine (5g) was safer than the reference drug, carbamazepine, with ED50 value of 93.9 mg.kg(-1) and protective index (PI) value of 24.3, which was a potential anti-epilepsy candidate compound.
A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 2935-35-5. Product Details of 2935-35-5.
Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem