Chemistry can be defined as the study of matter and the changes it undergoes. You’ll sometimes hear it called the central science because it is the connection between physics and all the other sciences, starting with biology. 613-45-6, Name is 2,4-Dimethoxybenzaldehyde, molecular formula is , belongs to phthalazine compound. In a document, author is Romero, Angel H., Recommanded Product: 2,4-Dimethoxybenzaldehyde.
Aryl- or heteroaryl-based hydrazinylphthalazine derivatives as new potential antitrypanosomal agents
A series of twenty phthalazinyl-hydrazones were synthesized and tested as potential anti-Trypanosoma cruzi agents. The phthalazines containing 5-nitroheteroaryl moiety 3l and 3m displayed an excellent in vitro antitrypanosomal profile, exhibiting low micromolar EC50 values against proliferative epimastigote of T. cruzi and minimal toxicity toward Vero cells. These derivatives were more potent than the reference drug benznidazole against the epimastigote stage of the parasite. Structure-property analysis indicates that the highly conjugated 5-nitroheteroaryl moiety connected to the phthalazin scaffold play an important role in the antichagasic activity of these phthalazines. The decrease on the mitochondrial dehydrogenase activity and significant ROS production found for the parasites treated with 3l and 3m suggest that both nitro-derivatives can act through an oxidative stress mechanism. (C) 2017 Elsevier Inc. All rights reserved.
Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 613-45-6, in my other articles. Recommanded Product: 2,4-Dimethoxybenzaldehyde.
Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem