Children learn through play, and they learn more than adults might expect. Science experiments are a great way to spark their curiosity, Category: phthalazines23981-47-7, Name is 2-(6-Methoxynaphthalen-2-yl)acetic acid, SMILES is O=C(O)CC1=CC=C2C=C(OC)C=CC2=C1, belongs to phthalazine compound. In a article, author is Shahsavani, Mohammad Bagher, introduce new discover of the category.
Anticancer activity assessment of two novel binuclear platinum (II) complexes
In the current study, two binuclear Pt (II) complexes, containing cis, cis-[Me2Pt (mu-NN) (mu-dppm) PtMe2] (1), and cis,cis-[Me2Pt(mu-NN)(mu dppm,) Pt((CH2)(4))] (2) in which NN = phthalazine and dppm = bis (diphenylphosphino) methane were evaluated for their anticancer activities and DNA/purine nucleotide binding properties. These Pt (II) complexes, with the non-classical structures, demonstrated a significant anticancer activity against Jurkat and MCF-7 cancer cell lines. The results of ethidium bromide/acridine orange staining and Caspase-III activity suggest that these complexes were capable to stimulate an apoptotic mechanism of cell death in the cancer cells. Using different biophysical techniques and docking simulation analysis, we indicated that these complexes were also capable to interact efficiently with DNA via a non-intercalative mechanism. According to our results, substitution of cyclopentane (in complex 2) with two methyl groups (in complex 1) results in significant improvement of the complex ability to interact with DNA and subsequently to induce the anticancer activity. Overall, these binuclear Pt (II) complexes are promising group of the non-classical potential anticancer agents which can be considered as molecular templates in designing of highly efficient platinum anticancer drugs. (C) 2016 Elsevier B.V. All rights reserved.
Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions. you can also check out more blogs about 23981-47-7. Category: phthalazines.
Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem