Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 88-99-3, Name is Pathalic acid, molecular formula is C8H6O4, belongs to phthalazine compound. In a document, author is Ji, Dezhong, introduce the new discover, Safety of Pathalic acid.
A series of anthranilamide derivatives were designed and synthesized as novel smoothened (SMO) inhibitors based on the SMO inhibitor taladegib (LY2940680), which can also inhibit the SMO-D473H mutant, via a ring-opening strategy. The phthalazine core in LY2940680 was replaced with anthranilamide, which retained the inhibitory activity towards the hedgehog (Hh) signaling pathway as evidenced by a dual luciferase reporter gene assay. Compound 12a displayed the best inhibitory activity against the Hh signaling pathway with IC50 value of 34.09 nM, and exhibited better proliferation inhibitory activity towards the Daoy cell line (IC50=0.48 mu M) than LY2940680 (IC50=0.79 mu M).
Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law. In my other articles, you can also check out more blogs about 88-99-3. Safety of Pathalic acid.
Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem