In an article, author is Abou-Seri, Sahar M., once mentioned the application of 696-63-9, Quality Control of 4-Methoxythiophenol, Name is 4-Methoxythiophenol, molecular formula is C7H8OS, molecular weight is 140.2, MDL number is MFCD00004849, category is phthalazine. Now introduce a scientific discovery about this category.
In our endeavor towards the development of effective VEGFR-2 inhibitors, three novel series of phthalazine derivatives based on 1-piperazinyl-4-arylphthalazine scaffold were synthesized. All the newly prepared phthalazines 16a-k, 18a-e and 21a-g were evaluated in vitro for their inhibitory activity against VEGFR-2. In particular, compounds 16k and 21d potently inhibited VEGFR-2 at sub-micromolar IC50 values 0.35 +/- 0.03 and 0.40 +/- 0.04 mu M, respectively. Moreover, seventeen selected compounds 16c-e, 16g, 16h, 16j, 16k, 18c-e and 21a-g were evaluated for their in vitro anticancer activity according to US-NCI protocol, where compounds 16k and 21d proved to be the most potent anticancer agents. While, compound 16k exhibited potent broad spectrum anticancer activity with full panel GI(50) (MG-MID) value of 3.62 mu M, compound 21d showed high selectivity toward leukemia and prostate cancer subpanels [subpanel GI(50) (MG-MID) 3.51 and 5.15 mu M, respectively]. Molecular docking of compounds16k and 21d into VEGFR-2 active site was performed to explore their potential binding mode. (C) 2015 Elsevier Masson SAS. All rights reserved.
Interested yet? Read on for other articles about 696-63-9, you can contact me at any time and look forward to more communication. Quality Control of 4-Methoxythiophenol.
Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem