In an article, author is Karishma, Pidiyara, once mentioned the application of 622-88-8, Category: phthalazines, Name is (4-Bromophenyl)hydrazine hydrochloride, molecular formula is C6H8BrClN2, molecular weight is 223.4981, MDL number is MFCD00012941, category is phthalazine. Now introduce a scientific discovery about this category.
A direct carbocyclization of 2-aryl-2,3-dihydrophthalazine-1,4-diones is achieved using isocyanates as carbonyl source via Ru(II)-catalyzed sequential ortho-amidation followed by intramolecular nucleophilic substitution, delivering substituted indazolo[1,2-b]phthalazine-triones in good-to-excellent yields. For ortho-substituted 2-aryl-2,3-dihydrophthalazine-1,4-diones, the corresponding amidated products were also isolated in excellent yields by modifying the reaction parameters. Application of isocyanates as carbonyl source, high functional group tolerance on the two coupling partners and diverse chemical transformation of the synthesized fused and functionalized phthalazinones are the key highlights of the work.
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Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem