Brief introduction of 42972-13-4

The synthetic route of 42972-13-4 has been constantly updated, and we look forward to future research findings.

42972-13-4, 1,4-Dioxo-1,2,3,4-tetrahydrophthalazine-6-carboxylic acid is a phthalazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

l-Bromo-4-oxo-3,4-dihydro-phthalazine-6-carboxylic acidl,4-Dioxo-l,2,3,4-tetrahydro-phthalazine-6-carboxylic acid (91.Og, 0.44mol) was suspended in dichloroethane (1.0L) and phosphorus pentabromide (761.Og,1.77mol) was added in three portions and the reaction heated to reflux for 24 hours. The reaction was cooled to room temperature and poured onto ice (2.50kg) EPO and the resulting precipitate filtered and washed with water to give the crude product (13Og).This crude material was suspended in acetic acid (1.60L) and heated to 125C for 2 hours. The reaction was cooled to room temperature and poured onto ice (1.5kg) and the resulting precipitate filtered. The solid was washed with water and dried to give the title compound (85g, 73% yield) as a yellow solid. MS (ESI+) = (M+H)+ 310 & 312

The synthetic route of 42972-13-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; F. HOFFMANN-LA ROCHE AG; WO2006/32518; (2006); A1;,
Phthalazine – Wikipedia
Phthalazine | C8H6N2 – PubChem