Chemistry can be defined as the study of matter and the changes it undergoes. You’ll sometimes hear it called the central science because it is the connection between physics and all the other sciences, starting with biology. 108-36-1, Name is 1,3-Dibromobenzene, molecular formula is , belongs to phthalazine compound. In a document, author is Xin Jingchao, Recommanded Product: 108-36-1.
In order to find more efficient and economical antitumor drugs, a series of 1-phenyl-4-substituted phthalazine derivatives were synthesized and evaluated for antiproliferative activity in vivo. The structures of the synthesized compounds were confirmed by H-1 NMR, C-13 NMR and HRMS. The antitumor activity of the target compounds was performed against four cancer cell lines by 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2-H-tetrazolium bromide (MTT). The results showed that some compounds had a good antitumor activity, especially, N-(4-methoxyphenyl)-2-((4-phenylphthalazin-1-yl)thio)acetamide (5f) and N-(3-chloro-4-fluorophenyl)-2-(4-(4-phenylphthalazin-1-yl)piperazin-1-yl)acetamide (8c), exhibited better antitumor activities with IC50 values of 8.13 and 9.31 mu mol.L-1 against the human esophageal cancer cells, which were superior to 5-fuorouracil.
Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 108-36-1, in my other articles. Recommanded Product: 108-36-1.
Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem