Chemistry is traditionally divided into organic and inorganic chemistry. The former is the study of compounds containing at least one carbon-hydrogen bonds. 89-86-1, Name is 2,4-Dihydroxybenzoic acid, molecular formula is C7H6O4, belongs to phthalazine compound, is a common compound. In a patnet, author is Cui, Zhi-Ming, once mentioned the new application about 89-86-1, Quality Control of 2,4-Dihydroxybenzoic acid.
Inspired by sanguinarine and chelerythrine, a novel antifungal 2-phenylphthalazin-2-ium scaffold as a simple analogue was designed. Most of the 30 compounds showed excellent inhibition activity against almost all eight phytopathogenic fungi, far superior to sanguinarine and chelerythrine. A third of the compounds were more active than azoxystrobin in most cases. Compounds 26 and 27 showed the highest total activity against all the fungi with EC50 means of ca. 4.6 mu g/mL. Fusarium solani showed the highest susceptibility with an EC50 mean of 3.62 mu g/mL to 19 compounds. A concentration of 25.0 mu g/mL 27 can fully control the Colletotrichum gloeosporioides infection in apples over 9 days. Electron microscopic observations showed that 27 was able to damage the structures of the hypha and cell membrane. The structure-activity relationship showed that the presence of electron-withdrawing groups on the C-ring increases the activity against most of the fungi. Thus, 2-phenylphthalazin-2-ium compounds represent promising leads for the development of novel fungicides.
We’ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, 89-86-1. The above is the message from the blog manager. Quality Control of 2,4-Dihydroxybenzoic acid.
Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem