Recommanded Product: 1-(Trifluoromethyl)-4-vinylbenzene, In classical electrochemical theory, both the electron transfer rate and the adsorption of reactants at the electrode control the electrochemical reaction. 402-50-6, Name is 1-(Trifluoromethyl)-4-vinylbenzene, SMILES is FC(F)(F)C1=CC=C(C=C)C=C1, belongs to phthalazine compound. In a article, author is Sanchez-Moreno, Manuel, introduce new discover of the category.
A series of new phthalazine derivatives 1-4 containing imidazole rings were prepared. The monoalkylamino substituted. derivatives 2 and 4 were more active in vitro against T. cruzi and less toxic against Vero cells than both their disubstituted analogues and the reference drug benznidazole. Compounds 2 and 4 highly inhibited the antioxidant parasite enzyme Fe-SOD, and molecular modeling suggested that they interact with the H-bonding system of the iron atom moiety. In vivo tests on the acute phase of Chagas disease gave parasitemia inhibition values twice those of benznidazole, and a remarkable decrease in the reactivation of parasitemia was found in the chronic phase for immunodeficient mice. Glucose metabolism studies showed that compounds 1-4 did not affect the succinate pathway but originated important changes in the excretion of pyruvate metabolites. The morphological alterations found in epimastigotes treated with 1-4 confirmed extensive cytoplasm damage and a high mortality rate of parasites.
Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law. In my other articles, you can also check out more blogs about 402-50-6. Recommanded Product: 1-(Trifluoromethyl)-4-vinylbenzene.
Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem