Researchers are common within chemical engineering and are often tasked with creating and developing new chemical techniques, frequently combining other advanced and emerging scientific areas. Safety of (4-Bromophenyl)hydrazine hydrochloride, 622-88-8, Name is (4-Bromophenyl)hydrazine hydrochloride, SMILES is NNC1=CC=C(Br)C=C1.[H]Cl, in an article , author is Malinowski, Zbigniew, once mentioned of 622-88-8.
The synthesis of a series of new alkylsulfanyl phthalazinone and phthalazine derivatives is described. The target compounds were efficiently synthesized in a four step sequence, consisting of (1) cyclization of 2-formylbenzoic acid with hydrazine hydrate to form phthalazinone, (2) the direct bromination of phthalazinone core with KBr3, (3) alkylation of the obtained 4-bromolactam (Mitsunobu procedure) to make N- and also O-alkyl derivatives and finally (4) palladium-catalyzed coupling reactions of 2-alkyl-4bromophthalazinone and 1-allcyloxy-4-bromophthalazine derivatives with aliphatic mercaptanes. Furthermore, the synthesis of 2-methyl-8-(propan-2-yl)sulfanyl-pyrido[3,44pyridazin-1(2H)-one from 2methyl-pyrido[3,4-d]pyridazin-1(2H)-one via bromination reaction with KBr3 and subsequent sulfanylation by isopropyl mercaptan under catalyzed coupling reaction conditions is also described. (C) 2016 Elsevier Ltd. All rights reserved.
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Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem