The dynamic chemical diversity of the numerous elements, ions and molecules that constitute the basis of life provides wide challenges and opportunities for research. In an article, author is Genovino, Julien, once mentioned the application of 643-79-8, Name is Benzene-1,2-dicarboxaldehyde, molecular formula is C8H6O2, molecular weight is 134.132, MDL number is MFCD00003335, category is phthalazine. Now introduce a scientific discovery about this category, HPLC of Formula: https://www.ambeed.com/products/643-79-8.html.
The isolation, quantitation, and characterization of drug metabolites in biological fluids remain challenging. Rapid access to oxidized drugs could facilitate metabolite identification and enable early pharmacology and toxicity studies. Herein, we compared biotransformations to classical and new chemical C-H oxidation methods using oxcarbazepine, naproxen, and an early compound hit (phthalazine 1). These studies illustrated the low preparative efficacy of biotransformations and the inability of chemical methods to oxidize complex pharmaceuticals. We also disclose an aerobic catalytic protocole (CuI/air) to oxidize tertiary amines and benzylic CH’s in drugs. The reaction tolerates a broad range of functionalities and displays a high level of chemoselectivity, which is not generally explained by the strength of the C-H bonds but by the individual structural chemotype. This study represents a first step toward establishing a chemical toolkit (chemotransformations) that can selectively oxidize C-H bonds in complex pharmaceuticals and rapidly deliver drug metabolites.
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Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem