The prevalence of solvent effects in heterogeneous catalysis in condensed media has motivated developing quantitative kinetic, and theoretical assessments of solvent structures and their interactions with reaction intermediates and transition states. 1149-26-4, Name is Z-L-Val-OH, molecular formula is C13H17NO4, belongs to phthalazine compound. In a document, author is Amin, Kamilia M., introduce the new discover, Safety of Z-L-Val-OH.
Efforts to develop new antitumor agents are now directed towards multitarget therapies that are believed to have high potency and low tendency to resistance compared to conventional drugs. Herein, we highlighted the synthesis and antitumor activity of five series of phthalazine-based compounds featuring a variety of bioactive chemical fragments at position 1 of the phthalazine nucleus. The antitumor activity of the target compounds was performed against fourteen cancer cell lines where all compounds were active in the nanomolar level. In addition, the mechanism of action of the target compounds was investigated through an enzymatic inhibitory assay against VEGFR-2 and EGFR kinases, revealing potent and preferential activity toward VEGFR-2. Binding mode of the most active compounds was studied using docking experiment. (C) 2016 Elsevier Masson SAS. All rights reserved.
If you’re interested in learning more about 1149-26-4. The above is the message from the blog manager. Safety of Z-L-Val-OH.
Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem