Chemical engineers ensure the efficiency and safety of chemical processes, adapt the chemical make-up of products to meet environmental or economic needs, and apply new technologies to improve existing processes. 524-95-8, Name is 2-((Diphenylboryl)oxy)ethanamine, SMILES is NCCOB(C1=CC=CC=C1)C2=CC=CC=C2, belongs to phthalazine compound. In a document, author is Xin Jingchao, introduce the new discover, Recommanded Product: 2-((Diphenylboryl)oxy)ethanamine.
In order to find more efficient and economical antitumor drugs, a series of 1-phenyl-4-substituted phthalazine derivatives were synthesized and evaluated for antiproliferative activity in vivo. The structures of the synthesized compounds were confirmed by H-1 NMR, C-13 NMR and HRMS. The antitumor activity of the target compounds was performed against four cancer cell lines by 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2-H-tetrazolium bromide (MTT). The results showed that some compounds had a good antitumor activity, especially, N-(4-methoxyphenyl)-2-((4-phenylphthalazin-1-yl)thio)acetamide (5f) and N-(3-chloro-4-fluorophenyl)-2-(4-(4-phenylphthalazin-1-yl)piperazin-1-yl)acetamide (8c), exhibited better antitumor activities with IC50 values of 8.13 and 9.31 mu mol.L-1 against the human esophageal cancer cells, which were superior to 5-fuorouracil.
We’ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, 524-95-8. The above is the message from the blog manager. Recommanded Product: 2-((Diphenylboryl)oxy)ethanamine.
Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem