The dynamic chemical diversity of the numerous elements, ions and molecules that constitute the basis of life provides wide challenges and opportunities for research. In an article, author is Ramezani, Mahin, once mentioned the application of 90-64-2, Name is 2-Hydroxy-2-phenylacetic acid, molecular formula is C8H8O3, molecular weight is 152.1473, MDL number is MFCD00064250, category is phthalazine. Now introduce a scientific discovery about this category, Synthetic Route of 90-64-2.
In this paper we investigated reactions of urazole and phthalazine with N-(aryl)-2,2,2-trifluoroacetimidoyl chloride derivatives. Results showed that when imidoyl chloride derivative has a fluorine atom at ortho position (3a-c), in two steps under a S(N)i mechanism and then SNAr reaction mechanism produce ay1-5-(trifluoromethyl)-1H-benzo [el [1,2,4]triazolo[1,2-a] [1,2,4]triazine-1,3(2H)-diones (4a-c) and 6-(trifluoromethyl)benzo[5,6][1,2,4]triazino[1,2-b]phthalazine-8,13-diones (4i,4j) in good to excellent yields. In the other imidoyl derivatives (3d-h and 3i,3j) under these conditions cyclization reaction does not occur and therefore produce 1-aryl-2,2,2-trifluorornethyl)-4-phenyl-1,2,4-triazolidine-3,5-diones (4d-h) and 2-(2,2,2-trifluoro-1-(arylimino)ethyl)-2,3-dihydrophthalazine-1,4-diones(4k,41) (non-cyclic products) in good to excellent yields. (C) 2016 Elsevier B.V. All rights reserved.
Synthetic Route of 90-64-2, The reactant in an enzyme-catalyzed reaction is called a substrate. Enzyme inhibitors cause a decrease in the reaction rate of an enzyme-catalyzed reaction.I hope my blog about 90-64-2 is helpful to your research.
Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem