With the volume and accessibility of scientific research increasing across the world, it has never been more important to continue building the reputation for quality and ethical publishing we’ve spent the past two centuries establishing. 620-14-4, Name is 3-Ethyltoluene, SMILES is CC1=CC(CC)=CC=C1, in an article , author is Boulebd, Houssem, once mentioned of 620-14-4, Formula: https://www.ambeed.com/products/620-14-4.html.
Hydralazine (HZ) and dihydralazine (DHZ) are phthalazine derivatives substituted at position 1 (HZ) or positions 1 and 4 (DHZ) by a hydrazinyl substituent. These compounds are widely used for treating hypertension and heart failure, essentially acting as vasodilators on the arteries and arterioles. In this study, the antioxidant activity of HZ and DHZ in the gas phase and in physiological environments was investigated by thermodynamic and kinetic calculations. It was found that the HOO center dot radical scavenging activity of these compounds follows the formal hydrogen transfer (FHT) mechanism. The H abstraction of the N9-H bond plays a deciding role in the HOO center dot radical scavenging of HZ-1 and DHZ-I, whereas the HOO center dot radical scavenging activities of HZ-2 and DHZ-2 are defined by the dissociation of the N10-H and Nil-H bonds, respectively. The rate constants for the HOO center dot radical scavenging of the HZ and DHZ in the gas phase are in the range of 9.64 x 10(6) to 4.52 x 10(8) M-1 s(-1), whereas in aqueous solutions and the lipid medium they are in the range of 2.62 X 10(4) to 5.13 x 10(7) M-1 s(-1) and 5.75 x 10(4) to 6.66 x 10(6) M-1 s(-1), respectively. The HOO center dot radical scavenging of DHZ-1 and DHZ-2 is thus faster than that of the reference antioxidant compound Trolox in all the studied environments. Consistently, DHZs are not only vasodilators but also potent antioxidants.
Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law. In my other articles, you can also check out more blogs about 620-14-4. Formula: https://www.ambeed.com/products/620-14-4.html.
Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem