Application In Synthesis of 4-Nitrobenzoic acid. Recently I am researching about MYCOBACTERIUM-TUBERCULOSIS; CLINICAL CANDIDATE; DERIVATIVES; DISCOVERY; PYRIDINE; Q203, Saw an article supported by the Department of Science and Technology, Government of IndiaDepartment of Science & Technology (India) [GAP0584]; Council of Scientific and Industrial Research (CSIR)Council of Scientific & Industrial Research (CSIR) – India; UGC, Government of IndiaUniversity Grants Commission, India. Published in FUTURE SCI LTD in LONDON ,Authors: Makane, VB; Krishna, VS; Krishna, EV; Shukla, M; Mahizhaveni, B; Misra, S; Chopra, S; Sriram, D; Dusthackeer, VNA; Rode, HB. The CAS is 62-23-7. Through research, I have a further understanding and discovery of 4-Nitrobenzoic acid
Aim: In recent times, heterocyclic chemotypes are being explored for the development of new antimycobacterials that target the drug-resistant tuberculosis. Here, we are disclosing the 5-substitued 2-mercapto-1,3,4-oxadiazoles as potent antitubercular agents. Methodology: A small library of 2-mercapto-1,3,4-oxadiazoles was synthesized using various acids. The compounds were evaluated for antituberculosis activity against M. tuberculosis H37Rv. Results: Compound 8j was identified as antitubercular lead with MIC of 0.6g/ml against M. tuberculosis H37Rv. This compound was nontoxic to CHO-K1 cells and showed selectivity index of 39. Of note, 8j showed antitubercular activity against pre-extensively drug-resistant clinical isolate of Mycobacterium with MIC of 2g/ml. Conclusion: This study provides potent antitubercular agent which can be further optimized to discover novel antibiotics. [GRAPHICS] .
Application In Synthesis of 4-Nitrobenzoic acid. About 4-Nitrobenzoic acid, If you have any questions, you can contact Makane, VB; Krishna, VS; Krishna, EV; Shukla, M; Mahizhaveni, B; Misra, S; Chopra, S; Sriram, D; Dusthackeer, VNA; Rode, HB or concate me.
Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem