Recently I am researching about N-C CLEAVAGE; CARBOXYLIC-ACIDS; CATALYZED AMINOCARBONYLATION; AMINO-ACIDS; OXIDATIVE AMIDATION; FREE TRANSAMIDATION; SECONDARY AMIDES; ARYL IODIDES; METAL-FREE; ALDEHYDES, Saw an article supported by the Indiana Clinical and Translational Sciences Institute – National Institutes of Health, National Center for Advancing Translational Sciences, Clinical and Translational Sciences Award [UL1TR002529]; Indiana University-Purdue University Indianapolis (IUPUI); National Institute of Dental & Craniofacial Research grant [1R21DE029156-01]. Published in AMER CHEMICAL SOC in WASHINGTON ,Authors: Irving, CD; Floreancig, JT; Laulhe, S. The CAS is 62-23-7. Through research, I have a further understanding and discovery of 4-Nitrobenzoic acid. HPLC of Formula: C7H5NO4
We describe a methodology for the amidation of carboxylic acids by generating phosphonium salts in situ from N-chlorophthalimide and triphenylphosphine. Aliphatic, benzylic, and aromatic carboxylic acids can be transformed into their amide counter parts using primary and secondary amines. This functional group interconversion is achieved at room temperature in good to excellent yields. Mechanistic work shows the in situ formation of chloro- and imido-phosphonium salts that react as activating agents for carboxylic acids and generate an acyloxyphosphonium species.
HPLC of Formula: C7H5NO4. About 4-Nitrobenzoic acid, If you have any questions, you can contact Irving, CD; Floreancig, JT; Laulhe, S or concate me.
Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem