Computed Properties of C7H5NO4. Lin, HZ; Qiao, YT; Yang, HY; Li, Q; Chen, Y; Qu, W; Liu, WY; Feng, F; Sun, HP in [Lin, Hongzhi; Qiao, Yuting; Yang, Hongyu; Li, Qi; Sun, Haopeng] China Pharmaceut Univ, Dept Med Chem, Nanjing 211198, Jiangsu, Peoples R China; [Feng, Feng] Jiangsu Food & Pharmaceut Sci Coll, Huaian 223003, Peoples R China; [Chen, Yao] Nanjing Univ Chinese Med, Sch Pharm, Nanjing 210023, Jiangsu, Peoples R China; [Qu, Wei] China Pharmaceut Univ, Dept Nat Med Chem, Nanjing 211198, Jiangsu, Peoples R China; [Liu, Wenyuan] China Pharmaceut Univ, Dept Analyt Chem, Nanjing 210009, Jiangsu, Peoples R China published Design and evaluation of Nrf2 activators with 1,3,4-oxa/thiadiazole core as neuro-protective agents against oxidative stress in PC-12 cells in 2020.0, Cited 35.0. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7.
Oxidative stress plays vital roles in virous neurodegenerative diseases including Alzheimer’s disease. Activation of the transcription factor Nrf2 (nuclear factor erythroid 2-related factor 2), the key regulator of oxidative stress, may provide a new therapeutic strategy for these diseases. Herein we synthesized and evaluated a series of 1,3,4-oxa/thiadiazole core Nrf2 activators as neuroprotective agents. The representative compound 8 exhibited cytoprotective and Nrf2 activation effects in a neuron-like PC-12 cells. Additionally, compound 8 showed good membrane permeability, indicating this compound could penetrate blood-brain barrier (BBB) to reach central nervous system (CNS) as a neuro-protective agent. These results indicated that these Nrf2 activators with 1,3,4-oxa/thiadiazole core could serve as a new chemotype against oxidative stress in neurodegenerative diseases.
Computed Properties of C7H5NO4. About 4-Nitrobenzoic acid, If you have any questions, you can contact Lin, HZ; Qiao, YT; Yang, HY; Li, Q; Chen, Y; Qu, W; Liu, WY; Feng, F; Sun, HP or concate me.
Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem